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dc.title Vanadium derivatives act as growth factor--mimetic compounds upon differentiation and proliferation of osteoblast-like UMR106 cells en
dc.type Artículo es
dcterms.abstract The effect of different vanadium compounds on proliferation and differentiation was examined in osteoblast-like UMR106 cells. Vanadate increased the cell growth in a biphasic manner, the higher doses inhibiting cell progression. Vanadyl stimulated cell proliferation in a dose-responsive manner. Similar to vanadate, pervanadate increased osteoblast-like cell proliferation in a biphasic manner but no inhibition of growth was observed. Vanadyl and pervanadate were stronger stimulators of cell growth than vanadate. Only vanadate was able to regulate the cell differentiation as measured by cell alkaline phosphatase activity. These results suggest that vanadium derivatives behave like growth factors on osteoblast-like cells and are potential pharmacological tools in the control of cell growth. en
dcterms.extent 6 p. es
dcterms.issued 1995
dcterms.language Inglés es
dcterms.license Attribution 4.0 International (BY 4.0) es
dcterms.subject vanadium compounds en
dcterms.subject osteoblast-like cells en
dcterms.subject proliferation en
dcterms.subject differentiation en
dcterms.subject bone development en
dcterms.subject growth factors en
cic.version info:eu-repo/semantics/submittedVersion es Cortizo, Ana María es Etcheverry, Susana B. es
cic.lugarDesarrollo Centro de Geología Aplicada, Agua y Medio Ambiente es
dcterms.subject.materia Geología es
dcterms.isPartOf.issue vol. 145, no. 7 es
dcterms.isPartOf.series Molecular and cellular biochemistry es
cic.isPeerReviewed true es
cic.isFulltext true es


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