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dc.title A possible role of oxidative stress in the vanadium-induced cytotoxicity in the MC3T3E1 osteoblast and UMR106 osteosarcoma cell lines en
dc.type Artículo es
dcterms.abstract The cytotoxicity and free radical production induced by vanadium compounds were investigated in an osteoblast (MC3T3E1) and an osteosarcoma (UMR106) cell lines in culture. Vanadate induced cell toxicity, reactive oxygen species (ROS) formation and thiobarbituric acid reactive substances (TBARS) increased in a concentration-dependent manner (0.1–10 mM) after 4 h. The concentration–response curve of vanadate-induced cytotoxicity and oxidative stress in MC3T3E1 cells was shifted to the left of the UMR106 curve, suggesting a greater sensitivity of the non-transformed cells in comparison to the osteosarcoma UMR106 cells. Supplementing with vitamin E acetate (80 mM) significantly inhibited ROS and TBARS formation but did not improve the vanadate-dependent decrease in cell number. Other vanadium compounds (vanadyl, pervanadate, and VO:Aspi, a complex of vanadyl(IV) with aspirin) showed different degrees of cell toxicity and induced oxidative stress. Altogether these results suggest that oxidative stress is involved in vanadium induced osteoblastic cytotoxicity, although the mechanism is unknown. © 2000 Elsevier Science Ireland Ltd. All rights reserved. es
dcterms.extent 11 p. es
dcterms.issued 2016
dcterms.language Inglés es
dcterms.license Attribution 4.0 International (BY 4.0) es
dcterms.subject Vanadium en
dcterms.subject Lipid peroxidation en
dcterms.subject Reactive oxygen species en
dcterms.subject Cytotoxicity en
dcterms.subject Osteoblasts en
dcterms.subject Bone en
cic.version info:eu-repo/semantics/submittedVersion es Cortizo, Ana María es Bruzzone, Liliana es Molinuevo, Silvina es Etcheverry, Susana Beatriz es
cic.lugarDesarrollo Universidad Nacional de La Plata es
dcterms.subject.materia Geología es
dcterms.isPartOf.issue vol. 147 es
dcterms.isPartOf.series Toxicology es
cic.isPeerReviewed true es
cic.isFulltext true es


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