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dc.date.accessioned 2016-11-17T13:33:12Z
dc.date.available 2016-11-17T13:33:12Z
dc.identifier.uri http://digital.cic.gba.gob.ar/handle/11746/4727
dc.title Characterization of Poly(ε-caprolactone)/Polyfumarate Blends as Scaffolds for Bone Tissue Engineering en
dc.type Artículo es
dcterms.abstract There is considerable interest in the design of polymeric biomaterials that can be used for the repair of bone defects. In this study, we used ultrasound to prepare a compatibilized blend of poly(ε-caprolactone) (PCL) and poly(diisopropyl fumarate) (PDIPF). The formation of post-sonication inter-polymer coupling products was verified by SEC analysis of a blend with azo-labeled PDIPF. We also analyzed the physicochemical and mechanical properties of the compatibilized blend. When compared to PCL alone, the PCL/PDIPF blend showed no difference in its resistance as evaluated by the elastic modulus, although it did show a 50% decrease in ultimate tensile stress (P <0.05) and an 84% decrease in elongation-at-break (P <0.05). However, the mechanical properties of this blend were comparable to those of trabecular bone. We next evaluated biocompatibility of the PCL/PDIPF blend, and of homo-polymeric PCL and PDIPF films for comparison, with UMR106 andMC3T3E1 osteoblastic cells. Osteoblasts plated on the compatibilized blend adhered and proliferated more than on either homo-polymer, showed a greater number of cellular processes with a better organized actin cytoskeleton and expressed more type-I collagen and mineral, both markers of osteoblast phenotype. These results support the hypothesis that this new compatibilized blend could be useful in future applications for bone regeneration. en
dcterms.extent 16 p. es
dcterms.issued 2010
dcterms.language Inglés es
dcterms.license Attribution 4.0 International (BY 4.0) es
dcterms.subject Bone tissue engineering en
dcterms.subject Biocompatibility en
dcterms.subject poly(ε-caprolactone) en
dcterms.subject poly(dialkyl fumarates) en
dcterms.subject ultrasound en
cic.version info:eu-repo/semantics/submittedVersion es
dcterms.creator.author Fernández, Juan Manuel es
dcterms.creator.author Molinuevo, M. Silvina es
dcterms.creator.author Cortizo, Ana María es
dcterms.creator.author McCarthy, Antonio Desmond es
dcterms.creator.author Cortizo, María Susana es
cic.lugarDesarrollo Universidad Nacional de La Plata es
dcterms.subject.materia Ciencias Químicas es
dcterms.isPartOf.issue vol. 21 es
dcterms.isPartOf.series Journal of Biomaterials Science es
cic.isPeerReviewed true es
cic.isFulltext true es


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