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dc.date.accessioned 2016-11-17T14:00:11Z
dc.date.available 2016-11-17T14:00:11Z
dc.identifier.uri https://digital.cic.gba.gob.ar/handle/11746/4728
dc.title Osteoblast behavior on novel porous polymeric scaffolds en
dc.type Artículo es
dcterms.abstract Current efforts in bone tissue engineering have as one focus the search for a scaffold material that supports osteoblast proliferation, matrix mineralization, and, ultimately, bone formation. Electrospraying of polymer solutions has enabled the engineering of porous materials to meet current challenges in bone replacement therapies. Porous scaffolds of poly( -caprolactone)/poly(diisopropyl fumarate) compatibilized blend for bone tissue engineering were obtained by electrospraying technique in order to create a better osteophilic environment for the growth and differentiation of osteoblasts. Non-porous films having smooth surface were obtained by casting and used for comparison purposes. Studies on cell-scaffold interaction were carried out by culturing two osteoblastlike cell lines, MC3T3E1 and UMR106, on three-dimensional scaffolds and two-dimensional films. Growth, proliferation, and differentiation (alkaline phosphatase activity) of osteoblasts, were assessed. Scaffolds displayed a highly porous structure with interconnected pores formed by polymer microparticles, and higher hydrophobicity than the observed in non-porous films. The adhesion, proliferation and alkaline phosphatase activity of cells grown on the porous scaffolds increased significantly in comparison to those observed on flat films. The rough surface morphology of this novel scaffold enhances osteoblast response. These results suggest that electrosprayed porous scaffolds may be potentially used as tissue engineering scaffolds with high bone regenerative efficacy. en
dcterms.extent 7 p. es
dcterms.issued 2011
dcterms.language Inglés es
dcterms.license Attribution 4.0 International (BY 4.0) es
dcterms.subject Electrospraying en
dcterms.subject Bone Tissue engineering en
dcterms.subject Adhesion en
dcterms.subject Proliferation en
dcterms.subject Alkaline Phosphatase en
cic.version info:eu-repo/semantics/submittedVersion es
dcterms.creator.author Fernández, Juan Manuel es
dcterms.creator.author Cortizo, María Susana es
dcterms.creator.author Cortizo, Ana María es
dcterms.creator.author Abraham, Gustavo A. es
cic.lugarDesarrollo Universidad Nacional de La Plata es
dcterms.subject.materia Ciencias Químicas es
dcterms.isPartOf.issue vol. 1 es
dcterms.isPartOf.series Journal of Biomaterials and Tissue Engineering es
cic.isPeerReviewed true es
cic.isFulltext true es


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