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dc.date.accessioned 2018-03-05T13:55:12Z
dc.date.available 2018-03-05T13:55:12Z
dc.identifier.uri http://digital.cic.gba.gob.ar/handle/11746/6867
dc.title Circulating Ghrelin Acts on GABA Neurons of the Area Postrema and Mediates Gastric Emptying in Male Mice en
dc.type Artículo es
dcterms.abstract Ghrelin is known to act on the area postrema (AP), a sensory circumventricular organ located in the medulla oblongata that regulates a variety of important physiological functions. However, the neuronal targets of ghrelin in the AP and their potential role are currently unknown. In this study, we used wild-type and genetically modified mice to gain insights into the neurons of the AP expressing the ghrelin receptor [growth hormone secretagogue receptor (GHSR)] and their role. We show that circulating ghrelin mainly accesses the AP but not to the adjacent nucleus of the solitary tract. Also, we show that both peripheral administration of ghrelin and fasting induce an increase of c-Fos, a marker of neuronal activation, in GHSR-expressing neurons of the AP, and that GHSR expression is necessary for the fasting-induced activation of AP neurons. Additionally, we show that ghrelin-sensitive neurons of the AP are mainly g-aminobutyric acid (GABA)ergic, and that an intact AP is required for ghrelin-induced gastric emptying. Overall, we show that the capacity of circulating ghrelin to acutely induce gastric emptying in mice requires the integrity of the AP, which contains a population of GABA neurons that are a target of plasma ghrelin. en
dcterms.extent 14 p. es
dcterms.issued 2017
dcterms.language Inglés es
dcterms.license Attribution 4.0 International (BY 4.0) es
dcterms.subject Circulating Ghrelin Acts en
dcterms.subject GABA Neurons en
dcterms.subject Male Mice en
dcterms.subject Mediates Gastric Emptying en
cic.version info:eu-repo/semantics/publishedVersion es
dcterms.creator.author Cabral, Agustina es
dcterms.creator.author Cornejo, María P. es
dcterms.creator.author Fernandez, Gimena es
dcterms.creator.author De Francesco, Pablo es
dcterms.creator.author Garcia-Romero, Guadalupe es
dcterms.creator.author Uriarte, Maia es
dcterms.creator.author Zigman, Jeffrey M. es
dcterms.creator.author Portiansky, Enrique Leo es
dcterms.creator.author Reynaldo, Mirta Beatriz es
dcterms.creator.author Perelló, Mario es
cic.lugarDesarrollo Instituto Multidisciplinario de Biología Celular es
dcterms.subject.materia Endocrinología y Metabolismo es
dcterms.identifier.url Recurso Completo es
dcterms.identifier.other https://doi.org/10.1210/en.2016-1815 es
dcterms.isPartOf.issue vol. 158, no. 5 es
dcterms.isPartOf.series Endocrinology es
cic.isPeerReviewed true es
cic.isFulltext true es


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