Show simple item record 2020-08-25T12:53:00Z 2020-08-25T12:53:00Z
dc.title Surface modification vs sorption strength: study of nedaplatin drug supported on silica en
dc.type Artículo es
dcterms.abstract The interaction of nedaplatin drug with modified SiO2 (0 0 1) surfaces has been investigated within the framework of Density Functional Theory. Nedaplatin molecule is adsorbed spontaneously onto silica surfaces. Silica surface prevents drug degradation allowing the chemical attachment without any impact on the drug structure itself. The nedaplatin sorption is mainly governed by H-bonding interactions on hydrated and trimethylsilanefunctionalized surfaces, while the drug is major stabilized by NeO, OeO interactions and H partial dissociation on dehydrated silica. The differences on the adsorption strength could be used in future studies to control the drug release, developing delivery silica systems according therapy requirements. en
dcterms.extent 693-699 es
dcterms.issued 2019
dcterms.language Inglés es
dcterms.license Attribution-NonCommercial-ShareAlike 4.0 International (BY-NC-SA 4.0) es
dcterms.subject Drug delivery en
dcterms.subject Nedaplatin en
dcterms.subject Silica en
dcterms.subject Adsorption en
dcterms.subject DFT en
cic.version info:eu-repo/semantics/publishedVersion es Noseda Grau, Emilia es Román, G. es Díaz Compañy, Andrés Carlos Daniel es Brizuela, G. es Juan, Alfredo es Simonetti, Sandra es
cic.lugarDesarrollo Universidad Nacional del Sur es
dcterms.subject.materia Ciencias Químicas es
dcterms.identifier.url Recurso online es
dcterms.identifier.other es
dcterms.isPartOf.issue vol. 465 es
dcterms.isPartOf.series Applied Surface Science es
cic.isPeerReviewed true es
cic.isFulltext true es


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