A Molecular Imprinted Polymer as a Flow-Through Optical Sensor for Oxazepam

cic.isFulltext true es
cic.isPeerReviewed true es
cic.lugarDesarrollo Laboratorio de Investigación y Desarrollo de Métodos Analíticos es
cic.version info:eu-repo/semantics/publishedVersion es
dc.date.accessioned 2018-05-17T12:42:43Z
dc.date.available 2018-05-17T12:42:43Z
dc.identifier.uri https://digital.cic.gba.gob.ar/handle/11746/7496
dc.title A Molecular Imprinted Polymer as a Flow-Through Optical Sensor for Oxazepam en
dc.type Artículo es
dcterms.abstract A flow-through optosensing system for oxazepam recognition with fluorescence detection was performed by means of a molecular imprinted polymer based on its acid hydrolysis product, 2-amino-5-chlorobenzophenone. )e synthesis was conducted via a noncovalent imprinting methodology, using methacrylic acid as a functional monomer and ethylene glycol dimethacrylate as a cross-linking agent. Hydrolysis (types and concentration of acids), polymer retention capacity, binding properties, and elution (selectivity and reversibility) conditions were optimized. )e selected molecular imprinted polymer had a molar ratio composition of 1 : 6 : 45 (template : functional monomer : cross-linker). )e proposed method was applied to the determination of oxazepam in a pharmaceutical formulation. External standard calibration, standard additions calibration, and Youden’s calibration were carried out in order to evaluate constant and proportional errors due to the matrix. )e developed metabolite-based recognition system for benzodiazepines is an innovative procedure that could be followed in routine and quality control assays. en
dcterms.creator.author Machicote, Roberta G. es
dcterms.creator.author Castillo, Marcela A. es
dcterms.creator.author Pacheco, María Emilia es
dcterms.creator.author Bruzzone, Liliana es
dcterms.extent 7 p. es
dcterms.identifier.other doi:10.1155/2018/6302609 es
dcterms.identifier.url Recurso online es
dcterms.isPartOf.issue vol. 2018 es
dcterms.isPartOf.series Journal of Analytical Methods in Chemistry es
dcterms.issued 2018
dcterms.language Inglés es
dcterms.license Attribution 4.0 International (BY 4.0) es
dcterms.subject Oxazepam es
dcterms.subject benzodiazepines en
dcterms.subject.materia Ciencias Químicas es
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