A Molecular Imprinted Polymer as a Flow-Through Optical Sensor for Oxazepam

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dc.date.accessioned2018-05-17T12:42:43Z
dc.date.available2018-05-17T12:42:43Z
dc.identifier.urihttps://digital.cic.gba.gob.ar/handle/11746/7496
dc.titleA Molecular Imprinted Polymer as a Flow-Through Optical Sensor for Oxazepamen
dc.typeArtículoes
dcterms.abstractA flow-through optosensing system for oxazepam recognition with fluorescence detection was performed by means of a molecular imprinted polymer based on its acid hydrolysis product, 2-amino-5-chlorobenzophenone. )e synthesis was conducted via a noncovalent imprinting methodology, using methacrylic acid as a functional monomer and ethylene glycol dimethacrylate as a cross-linking agent. Hydrolysis (types and concentration of acids), polymer retention capacity, binding properties, and elution (selectivity and reversibility) conditions were optimized. )e selected molecular imprinted polymer had a molar ratio composition of 1 : 6 : 45 (template : functional monomer : cross-linker). )e proposed method was applied to the determination of oxazepam in a pharmaceutical formulation. External standard calibration, standard additions calibration, and Youden’s calibration were carried out in order to evaluate constant and proportional errors due to the matrix. )e developed metabolite-based recognition system for benzodiazepines is an innovative procedure that could be followed in routine and quality control assays.en
dcterms.creator.authorMachicote, Roberta G.es
dcterms.creator.authorCastillo, Marcela A.es
dcterms.creator.authorPacheco, María Emiliaes
dcterms.creator.authorBruzzone, Lilianaes
dcterms.extent7 p.es
dcterms.identifier.otherdoi:10.1155/2018/6302609es
dcterms.identifier.urlRecurso onlinees
dcterms.isPartOf.issuevol. 2018es
dcterms.isPartOf.seriesJournal of Analytical Methods in Chemistryes
dcterms.issued2018
dcterms.languageIngléses
dcterms.licenseAttribution 4.0 International (BY 4.0)es
dcterms.subjectOxazepames
dcterms.subjectbenzodiazepinesen
dcterms.subject.materiaCiencias Químicases
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