A Molecular Imprinted Polymer as a Flow-Through Optical Sensor for Oxazepam
| cic.isFulltext | true | es |
| cic.isPeerReviewed | true | es |
| cic.lugarDesarrollo | Laboratorio de Investigación y Desarrollo de Métodos Analíticos | es |
| cic.version | info:eu-repo/semantics/publishedVersion | es |
| dc.date.accessioned | 2018-05-17T12:42:43Z | |
| dc.date.available | 2018-05-17T12:42:43Z | |
| dc.identifier.uri | https://digital.cic.gba.gob.ar/handle/11746/7496 | |
| dc.title | A Molecular Imprinted Polymer as a Flow-Through Optical Sensor for Oxazepam | en |
| dc.type | Artículo | es |
| dcterms.abstract | A flow-through optosensing system for oxazepam recognition with fluorescence detection was performed by means of a molecular imprinted polymer based on its acid hydrolysis product, 2-amino-5-chlorobenzophenone. )e synthesis was conducted via a noncovalent imprinting methodology, using methacrylic acid as a functional monomer and ethylene glycol dimethacrylate as a cross-linking agent. Hydrolysis (types and concentration of acids), polymer retention capacity, binding properties, and elution (selectivity and reversibility) conditions were optimized. )e selected molecular imprinted polymer had a molar ratio composition of 1 : 6 : 45 (template : functional monomer : cross-linker). )e proposed method was applied to the determination of oxazepam in a pharmaceutical formulation. External standard calibration, standard additions calibration, and Youden’s calibration were carried out in order to evaluate constant and proportional errors due to the matrix. )e developed metabolite-based recognition system for benzodiazepines is an innovative procedure that could be followed in routine and quality control assays. | en |
| dcterms.creator.author | Machicote, Roberta G. | es |
| dcterms.creator.author | Castillo, Marcela A. | es |
| dcterms.creator.author | Pacheco, María Emilia | es |
| dcterms.creator.author | Bruzzone, Liliana | es |
| dcterms.extent | 7 p. | es |
| dcterms.identifier.other | doi:10.1155/2018/6302609 | es |
| dcterms.identifier.url | Recurso online | es |
| dcterms.isPartOf.issue | vol. 2018 | es |
| dcterms.isPartOf.series | Journal of Analytical Methods in Chemistry | es |
| dcterms.issued | 2018 | |
| dcterms.language | Inglés | es |
| dcterms.license | Attribution 4.0 International (BY 4.0) | es |
| dcterms.subject | Oxazepam | es |
| dcterms.subject | benzodiazepines | en |
| dcterms.subject.materia | Ciencias Químicas | es |
Archivos
Bloque original
1 - 1 de 1
Cargando...
- Nombre:
- A Molecular Imprinted Polymer.pdf-PDFA.pdf
- Tamaño:
- 1.52 MB
- Formato:
- Adobe Portable Document Format
- Descripción:
- Documento completo