Fructose Rich Diet-Induced High Plasminogen Activator Inhibitor-1 (PAI-1) Production in the Adult Female Rat: Protective Effect of Progesterone
| cic.isFulltext | true | es |
| cic.isPeerReviewed | true | es |
| cic.lugarDesarrollo | Instituto Multidisciplinario de Biología Celular | es |
| cic.version | info:eu-repo/semantics/publishedVersion | es |
| dc.date.accessioned | 2018-03-20T16:59:03Z | |
| dc.date.available | 2018-03-20T16:59:03Z | |
| dc.identifier.uri | https://digital.cic.gba.gob.ar/handle/11746/7036 | |
| dc.title | Fructose Rich Diet-Induced High Plasminogen Activator Inhibitor-1 (PAI-1) Production in the Adult Female Rat: Protective Effect of Progesterone | en |
| dc.type | Artículo | es |
| dcterms.abstract | The effect of progesterone (P4) on fructose rich diet (FRD) intake-induced metabolic, endocrine and parametrial adipose tissue (PMAT) dysfunctions was studied in the adult female rat. Sixty day-old rats were i.m. treated with oil alone (control, CT) or containing P4 (12 mg/kg). Rats ate Purina chow-diet ad libitum throughout the entire experiment and, between 100 and 120 days of age drank ad libitum tap water alone (normal diet; CT-ND and P4-ND) or containing fructose (10% w/v; CT-FRD and P4-FRD). At age 120 days, animals were subjected to a glucose tolerance test or decapitated. Plasma concentrations of various biomarkers and PMAT gene abundance were monitored. P4-ND (vs. CT-ND) rats showed elevated circulating levels of lipids. CT-FRD rats displayed high (vs. CT-ND) plasma concentrations of lipids, leptin, adiponectin and plasminogen activator inhibitor-1 (PAI-1). Lipidemia and adiponectinemia were high (vs. P4-ND) in P4-FRD rats. Although P4 failed to prevent FRD-induced hyperleptinemia, it was fully protective on FRD-enhanced plasma PAI-1 levels. PMAT leptin and adiponectin mRNAs were high in CT-FRD and P4-FRD rats. While FRD enhanced PMAT PAI-1 mRNA abundance in CT rats, this effect was absent in P4 rats. Our study supports that a preceding P4-enriched milieu prevented the enhanced prothrombotic risk induced by FRD-elicited high PAI-1 production. | en |
| dcterms.creator.author | Castrogiovanni, Daniel | es |
| dcterms.creator.author | Alzamendi, Ana | es |
| dcterms.creator.author | Ongaro, Luisina | es |
| dcterms.creator.author | Giovambattista, Andrés | es |
| dcterms.creator.author | Gaillard, Rolf | es |
| dcterms.creator.author | Spinedi, Eduardo | es |
| dcterms.extent | 14 p. | es |
| dcterms.identifier.other | DOI:10.3390/nu4081137 | es |
| dcterms.identifier.url | Recurso online | es |
| dcterms.isPartOf.issue | vol. 4, no. 8 | es |
| dcterms.isPartOf.series | Nutrients | es |
| dcterms.issued | 2012-08 | |
| dcterms.language | Inglés | es |
| dcterms.license | Attribution 4.0 International (BY 4.0) | es |
| dcterms.publisher | MDPI (Multidisciplinary Digital Publishing Institute) | es |
| dcterms.subject | high carbohydrate diet | en |
| dcterms.subject | glucose tolerance | en |
| dcterms.subject | insulin | en |
| dcterms.subject | adipokines | en |
| dcterms.subject | allostasis | es |
| dcterms.subject.materia | Biología Celular, Microbiología | es |
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