Effect of Pioglitazone on the Fructose-Induced Abdominal Adipose Tissue Dysfunction
| cic.isFulltext | true | es |
| cic.isPeerReviewed | true | es |
| cic.lugarDesarrollo | imbice | es |
| cic.version | info:eu-repo/semantics/publishedVersion | es |
| dc.date.accessioned | 2018-03-28T13:02:56Z | |
| dc.date.available | 2018-03-28T13:02:56Z | |
| dc.identifier.uri | https://digital.cic.gba.gob.ar/handle/11746/7076 | |
| dc.title | Effect of Pioglitazone on the Fructose-Induced Abdominal Adipose Tissue Dysfunction | en |
| dc.type | Artículo | es |
| dcterms.abstract | Aim. To test the potential role of PPARγ in the endocrine abdominal tissue dysfunction induced by feeding normal rats with a fructose rich diet (FRD) during three weeks. Methodology. Adult normal male rats received a standard commercial diet (CD) or FRD, (10% in drinking water) without or with pioglitazone (PIO) (i.p. 0.25mg/Kg BW/day; CD-PIO and FRD-PIO). Thereafter, we measured circulating metabolic, endocrine, and oxidative stress (OS) markers, abdominal adipose tissue (AAT) mass, leptin (LEP) and plasminogen activator inhibitor-1 (PAI-1) tissue content/expression, and leptin release by isolated adipocytes incubated with different concentrations of insulin. Results. Plasma glucose, insulin, triglyceride, TBARS, LEP, and PAI-1 levels were higher in FRD rats; PIO coadministration fully prevented all these increments. AAT adipocytes from FRD rats were larger, secreted a higher amount of LEP, and displayed decreased sensitivity to insulin stimulation; these effects were significantly ameliorated by PIO. Whereas AAT LEP and PAI-1 (mRNA) concentrations increased significantly in FRD rats, those of insulin-receptor-substrate- (IRS-) 1 and IRS-2 were reduced. PIO coadministration prevented FRD effects on LEP, PAI-1, and IRS-2 (fully) and IRS-1 (partially) mRNAs in AAT. Conclusion. PPARγ would play a relevant role in the development of the FRD-induced metabolicendocrine dysfunction. | en |
| dcterms.creator.author | Alzamendi, Ana | es |
| dcterms.creator.author | Giovambattista, Andrés | es |
| dcterms.creator.author | Garcia, María Elisa | es |
| dcterms.creator.author | Rebolledo, Oscar R. | es |
| dcterms.creator.author | Gagliardino, Juan José | es |
| dcterms.creator.author | Spinedi, Eduardo | es |
| dcterms.extent | 10 p. | es |
| dcterms.identifier.other | DOI: 10.1155/2012/259093 | es |
| dcterms.identifier.url | Recurso online | es |
| dcterms.isPartOf.issue | vol. 2012 | es |
| dcterms.isPartOf.series | PPAR Research | es |
| dcterms.issued | 2012 | |
| dcterms.language | Inglés | es |
| dcterms.license | Attribution 4.0 International (BY 4.0) | es |
| dcterms.publisher | Hindawi Publishing Corporation | es |
| dcterms.subject | fructose rich diet | en |
| dcterms.subject | endocrine abdominal tissue dysfunction | en |
| dcterms.subject.materia | Biología Celular, Microbiología | es |
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