Effect of Pioglitazone on the Fructose-Induced Abdominal Adipose Tissue Dysfunction

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cic.lugarDesarrolloimbicees
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dc.date.accessioned2018-03-28T13:02:56Z
dc.date.available2018-03-28T13:02:56Z
dc.identifier.urihttps://digital.cic.gba.gob.ar/handle/11746/7076
dc.titleEffect of Pioglitazone on the Fructose-Induced Abdominal Adipose Tissue Dysfunctionen
dc.typeArtículoes
dcterms.abstractAim. To test the potential role of PPARγ in the endocrine abdominal tissue dysfunction induced by feeding normal rats with a fructose rich diet (FRD) during three weeks. Methodology. Adult normal male rats received a standard commercial diet (CD) or FRD, (10% in drinking water) without or with pioglitazone (PIO) (i.p. 0.25mg/Kg BW/day; CD-PIO and FRD-PIO). Thereafter, we measured circulating metabolic, endocrine, and oxidative stress (OS) markers, abdominal adipose tissue (AAT) mass, leptin (LEP) and plasminogen activator inhibitor-1 (PAI-1) tissue content/expression, and leptin release by isolated adipocytes incubated with different concentrations of insulin. Results. Plasma glucose, insulin, triglyceride, TBARS, LEP, and PAI-1 levels were higher in FRD rats; PIO coadministration fully prevented all these increments. AAT adipocytes from FRD rats were larger, secreted a higher amount of LEP, and displayed decreased sensitivity to insulin stimulation; these effects were significantly ameliorated by PIO. Whereas AAT LEP and PAI-1 (mRNA) concentrations increased significantly in FRD rats, those of insulin-receptor-substrate- (IRS-) 1 and IRS-2 were reduced. PIO coadministration prevented FRD effects on LEP, PAI-1, and IRS-2 (fully) and IRS-1 (partially) mRNAs in AAT. Conclusion. PPARγ would play a relevant role in the development of the FRD-induced metabolicendocrine dysfunction.en
dcterms.creator.authorAlzamendi, Anaes
dcterms.creator.authorGiovambattista, Andréses
dcterms.creator.authorGarcia, María Elisaes
dcterms.creator.authorRebolledo, Oscar R.es
dcterms.creator.authorGagliardino, Juan Josées
dcterms.creator.authorSpinedi, Eduardoes
dcterms.extent10 p.es
dcterms.identifier.otherDOI: 10.1155/2012/259093es
dcterms.identifier.urlRecurso onlinees
dcterms.isPartOf.issuevol. 2012es
dcterms.isPartOf.seriesPPAR Researches
dcterms.issued2012
dcterms.languageIngléses
dcterms.licenseAttribution 4.0 International (BY 4.0)es
dcterms.publisherHindawi Publishing Corporationes
dcterms.subjectfructose rich dieten
dcterms.subjectendocrine abdominal tissue dysfunctionen
dcterms.subject.materiaBiología Celular, Microbiologíaes

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