Cancer is of rare occurrence in pediatrics and adolescence (10- 19 years of age). Within this group almost 70% of the neoplasms present in patients less than 5 years of age. We are reporting our experience on 224 adolescents with one solid tumor. 61% were males. The relative incidence of the lesions was: tumors of the central nervous system 30.5%, soft tissue sarcomas 22.7%, bone tumors 18.1%, germ-cell tumors 11.8%, carcinomas 6.3%, nephroblastoma 2.9%, and neuroblastoma 0.9%. Comparing two time periods (1984-89 and 1990-99) the free of disease survival time at 48 months was 39.4% (45/114) and 81.8% (90/110), respectively; 49% and 35.5% presented sequelae, respectively. Social adaptation after cure of the disease revealed that only 4/135 patients (2.9%) are at the University, while 37% and 53.3% are working (intermittently) and 13.3% and 15.5% live as a couple, respectively. In the latter group, 20 patients, 35% have 10 children; 6 are women, 3 had had pelvic tumors 2 of the in the ovary (germ-cell tumors).