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dc.title Fumarate copolymer–chitosan cross-linked scaffold directed to osteochondrogenic tissue engineering en
dc.type Artículo es
dcterms.abstract Natural and synthetic cross-linked polymers allow the improvement of cytocompatibility and mechanical properties of the individual polymers. In osteochondral lesions of big size it will be required the use of scaffolds to repair the lesion. In this work a borax cross-linked scaffold based on fumarate-vinyl acetate copolymer and chitosan directed to osteochondrondral tissue engineering is developed. The cross-linked scaffolds and physical blends of the polymers are analyzed in based on their morphology, glass transition temperature, and mechanical properties. In addition, the stability, degradation behavior, and the swelling kinetics are studied. The results demonstrate that the borax cross-linked scaffold exhibits hydrogel behavior with appropriated mechanical properties for bone and cartilage tissue regeneration. Bone marrow progenitor cells and primary chondrocytes are used to demonstrate its osteo- and chondrogenic properties, respectively, assessing the osteoand chondroblastic growth and maturation, without evident signs of cytotoxicity as it is evaluated in an in vitro system. en
dcterms.issued 2016
dcterms.language Inglés es
dcterms.license Attribution-NonCommercial-ShareAlike 4.0 International (BY-NC-SA 4.0) es
dcterms.subject Fumarate-vinyl acetate copolymer en
dcterms.subject Chitosan en
dcterms.subject Osteochondrondral tissue engineering en
cic.version info:eu-repo/semantics/publishedVersion es Lastra, María Laura es Molinuevo, María Silvina es Cortizo, Ana María es Cortizo, María Susana es
cic.lugarDesarrollo Laboratorio de Investigación en Osteopatías y Metabolismo Mineral es
cic.lugarDesarrollo Instituto de Investigaciones Fisicoquímicas Teóricas y Aplicadas es
dcterms.subject.materia Ciencias Biológicas es
dcterms.identifier.other doi:10.1002/mabi.201600219 es
dcterms.identifier.other ISSN:1616-5187 es
dcterms.isPartOf.issue vol. 17, no. 5 es
dcterms.isPartOf.series Macromolecular Bioscience es
cic.isPeerReviewed true es
cic.isFulltext true es
cic.institucionOrigen Laboratorio de Investigación en Osteopatías y Metabolismo Mineral es


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