Open Science (OS) is no more or less than sharing all the research processes and products during the life cycle of a research project. The challenge is to change minds for the application of OS principles, sustainable practices, cultural sensitivity, and innovation to promote and support OS. Dr. De Giusti explores the concepts and aspects of OS as a mindset that needs policies and leadership to address globally shared challenges such as OS in all policies; open research process; infrastructure; legal aspects; multilingual and diversity; funding; and also a lot of new knowledge related with sharing FAIR and CARE data on an open basis.