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dc.title Asociación entre polimorfismos del gen NAT2 y fisura labiopalatina no sindrómica en Argentina es
dc.type Artículo es
dcterms.abstract <strong>Background:</strong> NAT genes are considered candidate genes for the genetic predisposition to non-syndromic Cleft lip with or without cleft palate (NSCLP), since they codify for N-acetyltransferases, enzymes responsible for the biotransformation of arylamines, hydrazine drugs, and a great number of toxins and carcinogens present in diet, cigarette smoke, and environment. Aim: To determine the association between alleles determining slow acetylator phenotype and the risk of NSCLP.<strong> Material and methods:</strong> We analyzed *5 (481C>T), *6 (590G>A) and *7 (857G>A) alleles which determine the slow acetylator phenotype and *4 (wild type) allele by polymerase chain reaction/restriction fragment length polymorphism in 97 progenitor-case trios of NSCLP in Argentinian Obstetric Wards. We evaluated the transmission disequilibrium (TDT). Results: TDT showed a positive association between allele *5 and NSCLP (odds ratio=1.6; p=0.03). Conclusions: The presence of *5 allele is significantly higher in cases with congenital NSCLP. es
dcterms.extent p. 444-450 es
dcterms.issued 2015
dcterms.language Español es
dcterms.license Attribution 4.0 International (BY 4.0) es
dcterms.subject Arylamine N-Acetyltransferase en
dcterms.subject Cleft lip en
dcterms.subject Cleft palate en
cic.version info:eu-repo/semantics/publishedVersion es Santos, María Rita es Ramallo, Virginia es Muzzio, Marina es López Camelo, Jorge Santiago es Bailliet, Graciela es
cic.lugarDesarrollo Instituto Multidisciplinario de Biología Celular es
dcterms.subject.materia Genética Humana es
dcterms.subject.materia Odontología, Medicina y Cirugía Oral es
dcterms.identifier.url Documento completo es
dcterms.isPartOf.issue vol. 143 es
dcterms.isPartOf.series Revista Medica de Chile es
cic.isPeerReviewed true es
cic.isFulltext true es


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