Malameba locustae, the etiological agent of the debilitative amoebiasis of the orthopterans, causes pathologies in the Malpighian tubules and alterations in the excretory function that lead to decreases in vigor, longevity and fecundity of the affected host. The present review evaluates the potential of M. locustae for the microbial control of acridians in Argentina based on the available information from other regions of the world, and from the results obtained up to now in experimental work conducted on argentine acridians. The easiness of oral transmision, the high infectivity to several argentine acridian species of economic importance (Baeacris punctulatus, Dichroplus elongatus, Dichroplus pratensis, Dichroplus schulzi, Ronderosia bergi, Schistocerca cancellata), and the rare occurrence in natural communities of acridians in Argentina suggest that M. locustae could be of value for the control approach of colonization (introduction-establishment).