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dc.title Vectorial insulin secretion by pancreatic β-cells en
dc.type Artículo es
dcterms.abstract Morphological studies of pancreatic β-cells have suggested the presence of discrete sensory and secretory domains. In the present study we now provide functional evidence by demonstrating polarity of insulin release by HIT-T15 cells. A significant diffusion barrier across a twin chamber culture system was verified in the presence of confluent HIT-T15 cells. When stimulated with sulphonylurea, ionophore or high potassium, insulin was preferentially released into the lower chamber irrespective of whether secretagogues were added to the upper or lower chambers. Vectorial insulin secretion may be a significant determinant of islet hormone paracrine interactions in the maintenance of glucose homeostasis. es
dcterms.extent 4 p. es
dcterms.issued 1990
dcterms.language Inglés es
dcterms.license Attribution 4.0 International (BY 4.0) es
dcterms.subject Epithelial polarity en
dcterms.subject HIT-T15 β-cell/Insulin secretion en
cic.version info:eu-repo/semantics/submittedVersion es Cortizo, Ana María es Espinal, Joseph es Hammonds, Peter es
cic.lugarDesarrollo Universidad Nacional de La Plata es
dcterms.subject.materia Ciencias Químicas es
dcterms.isPartOf.issue vol. 272 es
dcterms.isPartOf.series FEBS Letters es
cic.isPeerReviewed true es
cic.isFulltext true es


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