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dc.date.accessioned 2016-10-28T13:03:18Z
dc.date.available 2016-10-28T13:03:18Z
dc.identifier.uri http://digital.cic.gba.gob.ar/handle/11746/4524
dc.title A vanadium / aspirin complex controlled release using a poly(ß-propiolactone) lm. en
dc.type Artículo es
dcterms.abstract A delivery system for vanadiumwas developed using poly(¯-propiolactone)(P¯PL) lms. The release kinetics of a complex of vanadium (IV) with aspirin (VOAspi) was evaluated with lms prepared from polymers of differentmolecularweights, as well as with variable drug load. A sustained release of vanadium over 7 days was achieved. The drug release kinetics depends on contributions from two factors: (a) diffusion of the drug; and (b) erosion of the P¯PL lm. The experimental data at an early stage of release were tted with a diffusion model, which allowed determination of the diffusion coef cient of the drug. VOAspi does not show strong interaction with the polymer, as demonstrated by the low apparent partition coef cient (approximately 10¡2). UMR106 osteosarcoma cells were used as a model to evaluate the anticarcinogenic effects of the VOAspi released from the P¯PL lm. VOAspi–P¯PL lm inhibited cell proliferation in a dose-response manner and induced formation of approximately half of the thiobarbituric acid reactive substances (TBARS), an index of lipid peroxidation, compared to that with free VOAspi in solution. The unloaded P¯PL lm did not generate cytotoxicity, as evaluated by cell growth and TBARS. Thus, the polymer-embedded VOAspi retained the antiproliferative effects showing lower cytotoxicity than the free drug. Results with VOAspi–P¯PL lms suggest that this delivery system may have promising biomedical and therapeutic applications. en
dcterms.extent 15 p. es
dcterms.issued 2001
dcterms.language Inglés es
dcterms.license Attribution 4.0 International (BY 4.0) es
dcterms.subject Poly(ß-propiolactone) en
dcterms.subject diffusion model en
dcterms.subject vanadium en
dcterms.subject osteosarcomacells en
dcterms.subject cell proliferation en
dcterms.subject antineoplastic en
dcterms.subject lipid peroxidation en
dcterms.subject sustained delivery en
cic.version info:eu-repo/semantics/submittedVersion es
dcterms.creator.author Cortizo, María Susana es
dcterms.creator.author Alessandrini, J. L. es
dcterms.creator.author Etcheverry, Susana B. es
dcterms.creator.author Cortizo, Ana María es
cic.lugarDesarrollo Universidad Nacional de La Plata es
dcterms.subject.materia Ciencias Químicas es
dcterms.isPartOf.issue vol. 12, no. 9 es
dcterms.isPartOf.series Journal of Biomaterials Science Polymer Edition es
cic.isPeerReviewed true es
cic.isFulltext true es
dcterms.title.subtitle Effects on osteosarcoma cells en


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