Modeling Drug Effects on Personalized 3D Models of the Heart: A Simulation Study

Sebastian, Rafael; Heidenreich, Elvio; Dux-Santoy, Lydia; Rodriguez, Jose F.; Ferrero, José Maria; Ferrero, José María; Saiz, Javier

Documento de conferencia . Statistical Atlases and Computational Models of the Heart, First International Workshop, STACOM 2010, and Cardiac Electrophysiological Simulation Challenge, CESC 2010, Held in Conjunction with MICCAI (Beijing, 2010) ; I International Workshop, STACOM 2010, and Cardiac Electrophysiological Simulation Challenge, CESC 2010, Held in Conjunction with MICCAI

Modeling Drug Effects on Personalized 3D Models of the Heart: A Simulation Study

Year

2010

Year: 2010

Abstract: The use of anti-arrhythmic drugs is common to treat heart rhythm disorders. Computational modeling and simulation are powerful tools that can be used to investigate the effects of specific drugs on cardiac electrophysiology. In this work a patient-specific anatomical heart model is built to study the effects of dofetilide, a drug that affects IKr current in cardiac cells. We study the multi-scale effects of the drug, from cellular to organ level, by simulating electrical propagation on tissue coupled cellular ion kinetics for several heart beats. Different cell populations configurations namely endocardial, midmyocardial and epicardial are used to test the effect of tissue heterogeneity. Results confirmed the expected effects of dofetilide at cellular level, increasing the action potential duration. Pseudo-ECGs obtained for each heart beat correlated well with cellular results showing prolongation of QT segment. These techniques can be applied over the development of more complex drugs that affect multiple cellular currents

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Origin info: Instituto de Investigaciones en Ingeniería Industrial
Subject: Ingenierías y Tecnologías
Keyword: Cardiac electrophysiology | Multi-scale modeling | Simulation | Drug modeling | Therapy planning | Drug cardio-toxicity
Lenguage: Inglés
Extension: 10 p.

Date of availability: 22 de agosto de 2017
Date of accession: 22 de agosto de 2017
Date issued: septiembre de 2010
Others identifiers: https://doi.org/10.1007/978-3-642-15835-3_23
URL to resource: https://digital.cic.gba.gob.ar/handle/11746/6011
Licence: Attribution-NonCommercial-NoDerivatives 4.0 International (BY-NC-ND 4.0)