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dc.title Relationship between the Balance of Hypertrophic/Hyperplastic Adipose Tissue Expansion and the Metabolic Profile in a High Glucocorticoids Model en
dc.type Artículo es
dcterms.abstract Adipose tissue (AT) expansion is the result of two processes: hyperplasia and hypertrophy; and both, directly or indirectly, depend on the adipogenic potential of adipocyte precursor cells (APCs). Glucocorticoids (GCs) have a potent stimulatory effect on terminal adipogenesis; while their effects on early stages of adipogenesis are largely unknown. In the present work, we study, in a model of high GC levels, the adipogenic potential of APCs from retroperitoneal AT (RPAT) and its relationship with RPAT mass expansion. We employed a model of hyper-adiposity (30- and 60-day-old rats) due to high endogenous GC levels induced by neonatal treatment with L-monosodium glutamate (MSG).We found that the RPAT APCs from 30-day-old MSG rats showed an increased adipogenic capacity, depending on the APCs’ competency, but not in their number. Analyses of RPAT adipocyte diameter revealed an increase in cell size, regardless of the rat age, indicating the prevalence of a hypertrophic process. Moreover, functional RPAT alterations worsened in 60-day-old rats, suggesting that the hyperplastic AT expansion found in 30-day-old animals might have a protective role. We conclude that GCs chronic excess affects APCs’ adipogenic capacity, modifying their competency. This change would modulate the hyperplastic/hypertrophic balance determining healthy or unhealthy RPAT expansion and, therefore, its functionality. en
dcterms.extent 16 p. es
dcterms.issued 2016-07
dcterms.language Inglés es
dcterms.license Attribution 4.0 International (BY 4.0) es
dcterms.subject retroperitoneal adipose tissue en
dcterms.subject adipogenesis en
dcterms.subject stromal vascular fraction cells en
dcterms.subject cell determination en
dcterms.subject adipogenic competency en
cic.version info:eu-repo/semantics/publishedVersion es Zubiría, Guillermina es Alzamendi, Ana es Moreno, Griselda es Portales, Andrea Estefanía es Castrogiovanni, Daniel es Spinedi, Eduardo es Giovambattista, Andrés es
cic.lugarDesarrollo Centro de Endocrinología Experimental y Aplicada es
dcterms.subject.materia Biología Celular, Microbiología es
dcterms.identifier.url Recurso online es
dcterms.identifier.other DOI: 10.3390/nu8070410 es
dcterms.isPartOf.issue vol. 8, no. 7 es
dcterms.isPartOf.series Nutrients es
cic.isPeerReviewed true es
cic.isFulltext true es


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