Characterization of Poly(ε-caprolactone)/Polyfumarate Blends as Scaffolds for Bone Tissue Engineering
| cic.isFulltext | true | es |
| cic.isPeerReviewed | true | es |
| cic.lugarDesarrollo | Universidad Nacional de La Plata | es |
| cic.version | info:eu-repo/semantics/submittedVersion | es |
| dc.date.accessioned | 2016-11-17T13:33:12Z | |
| dc.date.available | 2016-11-17T13:33:12Z | |
| dc.identifier.uri | https://digital.cic.gba.gob.ar/handle/11746/4727 | |
| dc.title | Characterization of Poly(ε-caprolactone)/Polyfumarate Blends as Scaffolds for Bone Tissue Engineering | en |
| dc.type | Artículo | es |
| dcterms.abstract | There is considerable interest in the design of polymeric biomaterials that can be used for the repair of bone defects. In this study, we used ultrasound to prepare a compatibilized blend of poly(ε-caprolactone) (PCL) and poly(diisopropyl fumarate) (PDIPF). The formation of post-sonication inter-polymer coupling products was verified by SEC analysis of a blend with azo-labeled PDIPF. We also analyzed the physicochemical and mechanical properties of the compatibilized blend. When compared to PCL alone, the PCL/PDIPF blend showed no difference in its resistance as evaluated by the elastic modulus, although it did show a 50% decrease in ultimate tensile stress (P <0.05) and an 84% decrease in elongation-at-break (P <0.05). However, the mechanical properties of this blend were comparable to those of trabecular bone. We next evaluated biocompatibility of the PCL/PDIPF blend, and of homo-polymeric PCL and PDIPF films for comparison, with UMR106 andMC3T3E1 osteoblastic cells. Osteoblasts plated on the compatibilized blend adhered and proliferated more than on either homo-polymer, showed a greater number of cellular processes with a better organized actin cytoskeleton and expressed more type-I collagen and mineral, both markers of osteoblast phenotype. These results support the hypothesis that this new compatibilized blend could be useful in future applications for bone regeneration. | en |
| dcterms.creator.author | Fernández, Juan Manuel | es |
| dcterms.creator.author | Molinuevo, M. Silvina | es |
| dcterms.creator.author | Cortizo, Ana María | es |
| dcterms.creator.author | McCarthy, Antonio Desmond | es |
| dcterms.creator.author | Cortizo, María Susana | es |
| dcterms.extent | 16 p. | es |
| dcterms.isPartOf.issue | vol. 21 | es |
| dcterms.isPartOf.series | Journal of Biomaterials Science | es |
| dcterms.issued | 2010 | |
| dcterms.language | Inglés | es |
| dcterms.license | Attribution 4.0 International (BY 4.0) | es |
| dcterms.subject | Bone tissue engineering | en |
| dcterms.subject | Biocompatibility | en |
| dcterms.subject | poly(ε-caprolactone) | en |
| dcterms.subject | poly(dialkyl fumarates) | en |
| dcterms.subject | ultrasound | en |
| dcterms.subject.materia | Ciencias Químicas | es |
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