Penetración de Cefalotina en líquido tisular de músculo y tejido muscular
| cic.isFulltext | true | es |
| cic.isPeerReviewed | true | es |
| cic.lugarDesarrollo | Universidad Nacional de La Plata | es |
| cic.parentType | Articulo | |
| cic.version | info:eu-repo/semantics/submittedVersion | es |
| dc.date.accessioned | 2016-08-19T19:28:12Z | |
| dc.date.available | 2016-08-19T19:28:12Z | |
| dc.identifier.uri | https://digital.cic.gba.gob.ar/handle/11746/3892 | |
| dc.title | Penetración de Cefalotina en líquido tisular de músculo y tejido muscular | es |
| dc.type | Comunicacion | es |
| dcterms.abstract | The aim ot fhe present work was to compare the penetration in muscle tissue fluid (MTF) and muscle tissue (MT) of cephalotin administered in rabbits. Animals were distributed in Trial 1 (n = 15) and Trial 2 ( n= 6). In the Trial 1 the animals were implanted in ischiotibial muscle with non reactive material cages. Animals recibed subcutaneously (sc) cephalotin (20 mg/kg) and blood, MTF and MT samples were recollected. In the Trial 2 the animals recibed cephalotin (20 mg/kg) intravenously (iv) and blood samples were recollected. Pharmacokinetic analysis were performed using a non-compartmental model. Results: terminal disposition rate constant (λz ) (serum iv) 1.43 ± 0.54, (serum sc) 1.90, (MTF) 0.57 and (MT) 1.80 h–1 ; elimination half-life (t1/2 ) (serum iv) 0.53 ± 0.13, (serum sc) 0.36, (MTF) 1.20 and (MT) 0.38 h; the area under the curve [AUC(0-6) ] (serum iv) 60.40 ± 38.20, (serum sc) 45.90, (MTF) 21.60 and (MT) 3.00 μg.ml–1 h. and the bioavailability (F) was 76%. The penetration of cephalotin in MTF and MT were. 47.70 and 6.43%, respectively. Cephalotin administered subcutaneously in rabbit presented higher bioavailability, distribution in extracelullar fluid and low penetration in muscle tissue. | en |
| dcterms.alternative | Cephalotin penetration into muscle tissue fluid and muscle tissue | en |
| dcterms.creator.author | Vita, Mariangeles | es |
| dcterms.creator.author | Lacunza, Josefina | es |
| dcterms.creator.author | Farina, Osvaldo H. | es |
| dcterms.creator.author | Rule, Roberto | es |
| dcterms.extent | p. 608-611 | es |
| dcterms.identifier.url | Recurso Completo | es |
| dcterms.isPartOf.issue | vol. 27, no. 4 | es |
| dcterms.isPartOf.series | Latin American Journal of Pharmacy | es |
| dcterms.issued | 2008-01-01 | |
| dcterms.language | Español | es |
| dcterms.license | Attribution 4.0 International (BY 4.0) | es |
| dcterms.subject | cephalotin | en |
| dcterms.subject | penetration | en |
| dcterms.subject | muscle tissue fluid and muscle tissue | en |
| dcterms.subject | rabbits | en |
| dcterms.subject.materia | Farmacología y Farmacia | es |
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