Study of Materials for Drugs Delivery: cis-[PtCl₂(NH₃)₂] Hydrolysis on Functionalized SiO₂(100) Surfaces

cic.isFulltexttruees
cic.isPeerReviewedtruees
cic.lugarDesarrolloUniversidad Nacional del Sur es
cic.versioninfo:eu-repo/semantics/publishedVersiones
dc.date.accessioned2018-03-22T17:41:08Z
dc.date.available2018-03-22T17:41:08Z
dc.identifier.urihttps://digital.cic.gba.gob.ar/handle/11746/7057
dc.titleStudy of Materials for Drugs Delivery: cis-[PtCl₂(NH₃)₂] Hydrolysis on Functionalized SiO₂(100) Surfacesen
dc.typeArtículoes
dcterms.abstractThe hydrolysis of the cis-platin drug on a SiO2(100) hydrated surface was investigated by computational modeling. The cisplatin molecule presents weak interactions with the neighbouring OH groups of the hydrated surface. The cisplatin hydrolysis is not favourable on the SiO2(100) surface. Consequently, the adsorption properties of SiO2(100) are improved considering the surface’s modification with K, Mg, or NH2 functional species. In general, the system is more stable and the molecule-surface distance is reduced when cisplatin is adsorbed on the promoted surfaces.The hydrolysis is a favourable process on the SiO2(100) functionalized surfaces. The cisplatin hydrolysis is most favoured when the surface is functionalized with the NH2 specie. The electron density exchange plays a main role in the adsorption process. cis-[PtCl2(NH3)2] and cis-[PtCl(NH3)2]+ are adsorbed on the functionalized surface via Cl–N and Cl–Si interactions, while the cis-[Pt(NH3)2]2+ complex is adsorbed through Pt–O, Pt–Si, and Pt–Hinteractions. After adsorption, the strength of the N–Si, Si–O, and N–H superficial bonds of the functionalized SiO2(100) changes favouring the interaction between the molecule and their complexes with the surface.en
dcterms.creator.authorDíaz Compañy, Andrés Carlos Danieles
dcterms.creator.authorBrizuela, G.es
dcterms.creator.authorSimonetti, S.es
dcterms.extent11 p.es
dcterms.identifier.otherDOI: 10.1155/2013/363209es
dcterms.identifier.urlRecurso onlinees
dcterms.isPartOf.issuevol. 2013es
dcterms.isPartOf.seriesJournal of Solid State Physicses
dcterms.issued2013
dcterms.languageIngléses
dcterms.licenseAttribution 4.0 International (BY 4.0)es
dcterms.publisherHindawi Publishing Corporationes
dcterms.subjecthydrolysisen
dcterms.subjectcisplatinen
dcterms.subject.materiaCiencias Físicases
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