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Cytotoxic effect of potato aspartic proteases (StAPs) on Jurkat T cells


StAPs are potato aspartic proteases with cytotoxic activity against plant pathogens and spermatozoa.StAPs cytotoxic activity is selective, since these proteins do not exert toxic effect on plant cells and erythrocytes. In this work, we investigated the capacity ofStAPs to exert cytotoxicity on human leukaemia cells. Obtained results show thatStAPs induce apoptosis on Jurkat T cells after a short time of incubation in a dose-dependent manner. However, no significative effect on the T lymphocytes viability was observed at allStAPs incubation times and concentrations tested. These results suggest thatStAPs can be conceptually promising leads for cancer therapy.

Palabras clave
Aspartic proteases
Antimicrobial plant proteins

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