Cytotoxic effect of potato aspartic proteases (StAPs) on Jurkat T cells
| cic.isFulltext | true | es |
| cic.isPeerReviewed | true | es |
| cic.lugarDesarrollo | Instituto de Investigaciones Biológicas | es |
| cic.version | info:eu-repo/semantics/submittedVersion | es |
| dc.date.accessioned | 2017-03-17T13:34:33Z | |
| dc.date.available | 2017-03-17T13:34:33Z | |
| dc.identifier.uri | https://digital.cic.gba.gob.ar/handle/11746/5364 | |
| dc.title | Cytotoxic effect of potato aspartic proteases (StAPs) on Jurkat T cells | en |
| dc.type | Artículo | es |
| dcterms.abstract | <em>St</em>APs are potato aspartic proteases with cytotoxic activity against plant pathogens and spermatozoa.<em>St</em>APs cytotoxic activity is selective, since these proteins do not exert toxic effect on plant cells and erythrocytes. In this work, we investigated the capacity of<em>St</em>APs to exert cytotoxicity on human leukaemia cells. Obtained results show that<em>St</em>APs induce apoptosis on Jurkat T cells after a short time of incubation in a dose-dependent manner. However, no significative effect on the T lymphocytes viability was observed at all<em>St</em>APs incubation times and concentrations tested. These results suggest that<em>St</em>APs can be conceptually promising leads for cancer therapy. | en |
| dcterms.creator.author | Mendieta, Julieta Renée | es |
| dcterms.creator.author | Fimognari, Carmela | es |
| dcterms.creator.author | Daleo, Gustavo Raúl | es |
| dcterms.creator.author | Hrelia, Patrizia | es |
| dcterms.creator.author | Guevara, María G. | es |
| dcterms.extent | 7 p. | es |
| dcterms.identifier.url | Recurso Completo | es |
| dcterms.isPartOf.issue | vol. 81 | es |
| dcterms.isPartOf.series | Fitoterapia | es |
| dcterms.issued | 2010-10-13 | |
| dcterms.language | Inglés | es |
| dcterms.license | Attribution-NonCommercial-NoDerivatives 4.0 International (BY-NC-ND 4.0) | es |
| dcterms.subject | Aspartic proteases | en |
| dcterms.subject | Antimicrobial plant proteins | en |
| dcterms.subject | Apoptosis | en |
| dcterms.subject.materia | Biología Celular, Microbiología | es |
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