Human apolipoprotein A-I-derived amyloid: its association with atherosclerosis
| cic.isFulltext | true | es |
| cic.isPeerReviewed | true | es |
| cic.lugarDesarrollo | Universidad Nacional de La Plata | es |
| cic.version | info:eu-repo/semantics/submittedVersion | es |
| dc.date.accessioned | 2016-08-11T18:08:48Z | |
| dc.date.available | 2016-08-11T18:08:48Z | |
| dc.identifier.uri | https://digital.cic.gba.gob.ar/handle/11746/3616 | |
| dc.title | Human apolipoprotein A-I-derived amyloid: its association with atherosclerosis | en |
| dc.type | Artículo | es |
| dcterms.abstract | Amyloidoses constitute a group of diseases in which soluble proteins aggregate and deposit extracellularly in tissues. Nonhereditary apolipoprotein A-I (apoA-I) amyloid is characterized by deposits of nonvariant protein in atherosclerotic arteries. Despite being common, little is known about the pathogenesis and significance of apoA-I deposition. In this work we investigated by fluorescence and biochemical approaches the impact of a cellular microenvironment associated with chronic inflammation on the folding and pro-amyloidogenic processing of apoA-I. Results showed that mildly acidic pH promotes misfolding, aggregation, and increased binding of apoA-I to extracellular matrix elements, thus favoring protein deposition as amyloid like-complexes. In addition, activated neutrophils and oxidative/proteolytic cleavage of the protein give rise to pro amyloidogenic products. We conclude that, even though apoA-I is not inherently amyloidogenic, it may produce non hereditary amyloidosis as a consequence of the pro-inflammatory microenvironment associated to atherogenesis. | en |
| dcterms.creator.author | Ramella, Nahuel | es |
| dcterms.creator.author | Rimoldi, Omar J. | es |
| dcterms.creator.author | Prieto, Eduardo Daniel | es |
| dcterms.creator.author | Sánchez, Susana | es |
| dcterms.creator.author | Jaureguiberry, M. Soledad | es |
| dcterms.creator.author | Ferreira, Sergio T. | es |
| dcterms.creator.author | Tricerri, Alejandra | es |
| dcterms.creator.author | Schinella, Guillermo Raúl | es |
| dcterms.creator.author | Vela, María Elena | es |
| dcterms.extent | 11 p. | es |
| dcterms.identifier.other | 1932-6203 | es |
| dcterms.isPartOf.issue | vol. 6, no. 7 | es |
| dcterms.isPartOf.item | Informe científico de investigador: Vela, María Elena (2010-2011) | es |
| dcterms.isPartOf.series | PLoS ONE | es |
| dcterms.issued | 2011-01-01 | |
| dcterms.language | Inglés | es |
| dcterms.license | Attribution 4.0 International (BY 4.0) | es |
| dcterms.subject | Amiloidosis | es |
| dcterms.subject | Apolipoproteína A-I | es |
| dcterms.subject.materia | Ciencias Médicas y de la Salud | es |
| dcterms.subject.materia | Bioquímica y Biología Molecular | es |
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