Biodegradable polyester networks including hydrophilic groups favor BMSCs differentiation and can be eroded by macrophage action

cic.isFulltexttruees
cic.isPeerReviewedtruees
cic.lugarDesarrolloUniversidad Nacional de La Plata es
cic.versioninfo:eu-repo/semantics/submittedVersiones
dc.date.accessioned2016-11-18T18:30:38Z
dc.date.available2016-11-18T18:30:38Z
dc.identifier.urihttps://digital.cic.gba.gob.ar/handle/11746/4758
dc.titleBiodegradable polyester networks including hydrophilic groups favor BMSCs differentiation and can be eroded by macrophage actionen
dc.typeArtículoes
dcterms.abstractThe aim of this study is to show that introducing a small fraction of hydrophilic groups into a hydrophobic polyester favor the macrophage activity by accelerating the degradation action in aqueous media. It is also seen that differentiation of MSCs cultured in monolayer towards bone in specific differentiation media is favored in these materials with respect to the corresponding pristine polyesters. Polymer networks based in polycarpolactone or poly(l-lactide) and containing a small fraction of poly(hydroxyethyl acrylate) have been synthesized. Degradation kinetics<em>invitro</em>was monitored by mass loss and swelling capacity of the polymer network in good solvents, the later as representative of chain cleavage. Hydrolytic and enzymatic degradation is accelerated by the inclusion of poly(hydroxyethyl acrylate) blocks in the network. Macrophages were cultured on the surface of the network films, showing its capacity to erode the material surface but also to accelerate bulk degradation. Bone marrow mesenchymal stem cells were cultured in monolayer on the membranes in osteogenic media, showing an increase of specific markers expression in comparison to pristine polyesters.en
dcterms.creator.authorFernández, Juan Manueles
dcterms.creator.authorOberti, Tamara Giselaes
dcterms.creator.authorVikingsson, Linees
dcterms.creator.authorGómez Ribelles, José Luises
dcterms.creator.authorCortizo, Ana Maríaes
dcterms.extent9 p.es
dcterms.isPartOf.issuevol. 130es
dcterms.isPartOf.seriesPolymer Degradation and Stabilityes
dcterms.issued2016
dcterms.languageIngléses
dcterms.licenseAttribution 4.0 International (BY 4.0)es
dcterms.subjectPolycaprolactoneen
dcterms.subjectPoly(L-lactide)en
dcterms.subjectPoly(hydroxyethyl acrylate)en
dcterms.subjectMacrophage erosionen
dcterms.subjectEnzymatic degradationen
dcterms.subjectMesenchymal stem cellsen
dcterms.subject.materiaCiencias Químicases
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