Deleterious Metabolic Effects of High Fructose Intake: The Preventive Effect of Lactobacillus kefiri Administration

cic.isFulltext true es
cic.isPeerReviewed true es
cic.lugarDesarrollo Instituto Multidisciplinario de Biología Celular es
cic.version info:eu-repo/semantics/publishedVersion es 2018-03-20T16:51:57Z 2018-03-20T16:51:57Z
dc.title Deleterious Metabolic Effects of High Fructose Intake: The Preventive Effect of Lactobacillus kefiri Administration en
dc.type Artículo es
dcterms.abstract Modern lifestyle and diets have been associated with metabolic disorders and an imbalance in the normal gut microbiota. Probiotics are widely known for their health beneficial properties targeting the gut microbial ecosystem. The aim of our study was to evaluate the preventive effect of Lactobacillus kefiri (L. kefiri) administration in a fructose-rich diet (FRD) mice model. Mice were provided with tap water or fructose-added (20% w/v) drinking water supplemented or not with L. kefiri. Results showed that probiotic administration prevented weight gain and epidydimal adipose tissue (EAT) expansion, with partial reversion of the adipocyte hypertrophy developed by FRD. Moreover, the probiotic prevented the increase of plasma triglycerides and leptin, together with the liver triglyceride content. Leptin adipocyte secretion was also improved by L. kefiri, being able to respond to an insulin stimulus. Glucose intolerance was partially prevented by L. kefiri treatment (GTT) and local inflammation (TNFα; IL1β; IL6 and INFγ) was completely inhibited in EAT. L. kefiri supplementation generated an impact on gut microbiota composition, changing Bacteroidetes and Firmicutes profiles. Overall, our results indicate that the administration of probiotics prevents the deleterious effects of FRD intake and should therefore be promoted to improve metabolic disorders. en Zubiría, Guillermina es Gambaro, Sabrina Eliana es Rey, María Amanda es Carasi, Paula es Serradell, María de los Ángeles es Giovambattista, Andrés es
dcterms.extent 17 p. es
dcterms.identifier.other DOI: 10.3390/nu9050470 es
dcterms.identifier.url Recurso online es
dcterms.isPartOf.issue vol. 9, no. 5 es
dcterms.isPartOf.series Nutrients es
dcterms.issued 2017-05
dcterms.language Inglés es
dcterms.license Attribution 4.0 International (BY 4.0) es
dcterms.publisher MDPI (Multidisciplinary Digital Publishing Institute) es
dcterms.subject gut microbiota en
dcterms.subject fructose-rich diet en
dcterms.subject adipose tissue en
dcterms.subject probiotics en
dcterms.subject.materia Biología Celular, Microbiología es
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