Deleterious Metabolic Effects of High Fructose Intake: The Preventive Effect of Lactobacillus kefiri Administration

cic.lugarDesarrolloInstituto Multidisciplinario de Biología Celular es
dc.titleDeleterious Metabolic Effects of High Fructose Intake: The Preventive Effect of Lactobacillus kefiri Administrationen
dcterms.abstractModern lifestyle and diets have been associated with metabolic disorders and an imbalance in the normal gut microbiota. Probiotics are widely known for their health beneficial properties targeting the gut microbial ecosystem. The aim of our study was to evaluate the preventive effect of Lactobacillus kefiri (L. kefiri) administration in a fructose-rich diet (FRD) mice model. Mice were provided with tap water or fructose-added (20% w/v) drinking water supplemented or not with L. kefiri. Results showed that probiotic administration prevented weight gain and epidydimal adipose tissue (EAT) expansion, with partial reversion of the adipocyte hypertrophy developed by FRD. Moreover, the probiotic prevented the increase of plasma triglycerides and leptin, together with the liver triglyceride content. Leptin adipocyte secretion was also improved by L. kefiri, being able to respond to an insulin stimulus. Glucose intolerance was partially prevented by L. kefiri treatment (GTT) and local inflammation (TNFα; IL1β; IL6 and INFγ) was completely inhibited in EAT. L. kefiri supplementation generated an impact on gut microbiota composition, changing Bacteroidetes and Firmicutes profiles. Overall, our results indicate that the administration of probiotics prevents the deleterious effects of FRD intake and should therefore be promoted to improve metabolic disorders.en
dcterms.creator.authorZubiría, Guillerminaes
dcterms.creator.authorGambaro, Sabrina Elianaes
dcterms.creator.authorRey, María Amandaes
dcterms.creator.authorCarasi, Paulaes
dcterms.creator.authorSerradell, María de los Ángeleses
dcterms.creator.authorGiovambattista, Andréses
dcterms.identifier.otherDOI: 10.3390/nu9050470es
dcterms.identifier.urlRecurso onlinees
dcterms.isPartOf.issuevol. 9, no. 5es
dcterms.licenseAttribution 4.0 International (BY 4.0)es
dcterms.publisherMDPI (Multidisciplinary Digital Publishing Institute)es
dcterms.subjectgut microbiotaen
dcterms.subjectfructose-rich dieten
dcterms.subjectadipose tissueen
dcterms.subject.materiaBiología Celular, Microbiologíaes
Paquete original
Mostrando1 - 1 de 1
Imagen en miniatura
IMBICE-Deleterious Metabolic Effects of High Fructose.pdf-PDFA.pdf
1.97 MB
Adobe Portable Document Format
Documento completo