Standardizing training protocol of an intestinal transplantation model: A learning curve study

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cic.isFulltextSI
cic.isPeerReviewedSI
cic.lugarDesarrolloUniversidad Nacional de La Plata
cic.lugarDesarrolloInstituto de Estudios Inmunológicos y Fisiopatológicos (IIFP)
cic.lugarDesarrolloHospital Universitario La Paz
cic.lugarDesarrolloUniversidad Favaloro
cic.parentTypeArtículo
cic.versionPublicada
dc.date.accessioned2025-10-29T14:24:42Z
dc.date.available2025-10-29T14:24:42Z
dc.identifier.urihttps://digital.cic.gba.gob.ar/handle/11746/12574
dc.titleStandardizing training protocol of an intestinal transplantation model: A learning curve studyen
dc.typeArtículo
dcterms.abstractRodent models of intestinal transplantation are crucial for advancing our understanding of various biological processes related to the procedure, including ischemia-reperfusion injury, acute cellular rejection and immunological tolerance, among others. These models also provide a platform for developing strategies and therapeutics aimed at improving long-term survival, with the ultimate goal of translating laboratory findings into clinical applications. With over twenty years of experience in intestinal transplantation in rodents, our team currently achieves a survival rate of 83 % in orthotopic transplants and 85 % in heterotopic transplants—success rates comparable to those reported by leading research groups in the field. This manuscript outlines the key steps involved in achieving successful results in rat intestinal transplantation models. It covers the entire process, from basic microsurgical training and graft procurement to implantation and postoperative care of the recipient. We hope this work will serve as a valuable guide for research groups seeking to establish these experimental transplantation models in their own laboratories.en
dcterms.creator.authorAzpiroz, Josefina
dcterms.creator.authorAbate, Juan Cruz
dcterms.creator.authorAndres Moreno, Ane M.
dcterms.creator.authorMoreira, Jeremias
dcterms.creator.authorHernandez Oliveros, Francisco
dcterms.creator.authorRaimondi, Clemente J.
dcterms.creator.authorGondolesi, Gabriel
dcterms.creator.authorLausada, Natalia
dcterms.creator.authorStringa, Pablo
dcterms.identifier.otherDOI: 10.1016/j.intf.2025.100060
dcterms.identifier.otherISSN: 2950-4562
dcterms.identifier.urlhttps://www.intestinalfailurejournal.org/article/S2950-4562(25)00025-9/fulltext
dcterms.isPartOf.issuevol. 5
dcterms.isPartOf.seriesIntestinal Failure
dcterms.issued2025-05-31
dcterms.languageInglés
dcterms.licenseAttribution-NonCommercial-NoDerivatives 4.0 International (BY-NC-ND 4.0)
dcterms.subjectRatsen
dcterms.subjectResearchen
dcterms.subjectIntestinesen
dcterms.subjectTransplanten
dcterms.subjectRatsen
dcterms.subject.materiaCiencias Médicas

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