A vanadium / aspirin complex controlled release using a poly(ß-propiolactone) lm.

cic.isFulltexttruees
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cic.lugarDesarrolloUniversidad Nacional de La Plata es
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dc.date.accessioned2016-10-28T13:03:18Z
dc.date.available2016-10-28T13:03:18Z
dc.identifier.urihttps://digital.cic.gba.gob.ar/handle/11746/4524
dc.titleA vanadium / aspirin complex controlled release using a poly(ß-propiolactone) lm.en
dc.typeArtículoes
dcterms.abstractA delivery system for vanadiumwas developed using poly(¯-propiolactone)(P¯PL) lms. The release kinetics of a complex of vanadium (IV) with aspirin (VOAspi) was evaluated with lms prepared from polymers of differentmolecularweights, as well as with variable drug load. A sustained release of vanadium over 7 days was achieved. The drug release kinetics depends on contributions from two factors: (a) diffusion of the drug; and (b) erosion of the P¯PL lm. The experimental data at an early stage of release were tted with a diffusion model, which allowed determination of the diffusion coef cient of the drug. VOAspi does not show strong interaction with the polymer, as demonstrated by the low apparent partition coef cient (approximately 10¡2). UMR106 osteosarcoma cells were used as a model to evaluate the anticarcinogenic effects of the VOAspi released from the P¯PL lm. VOAspi–P¯PL lm inhibited cell proliferation in a dose-response manner and induced formation of approximately half of the thiobarbituric acid reactive substances (TBARS), an index of lipid peroxidation, compared to that with free VOAspi in solution. The unloaded P¯PL lm did not generate cytotoxicity, as evaluated by cell growth and TBARS. Thus, the polymer-embedded VOAspi retained the antiproliferative effects showing lower cytotoxicity than the free drug. Results with VOAspi–P¯PL lms suggest that this delivery system may have promising biomedical and therapeutic applications.en
dcterms.creator.authorCortizo, María Susanaes
dcterms.creator.authorAlessandrini, J. L.es
dcterms.creator.authorEtcheverry, Susana B.es
dcterms.creator.authorCortizo, Ana Maríaes
dcterms.extent15 p.es
dcterms.isPartOf.issuevol. 12, no. 9es
dcterms.isPartOf.seriesJournal of Biomaterials Science Polymer Editiones
dcterms.issued2001
dcterms.languageIngléses
dcterms.licenseAttribution 4.0 International (BY 4.0)es
dcterms.subjectPoly(ß-propiolactone)en
dcterms.subjectdiffusion modelen
dcterms.subjectvanadiumen
dcterms.subjectosteosarcomacellsen
dcterms.subjectcell proliferationen
dcterms.subjectantineoplasticen
dcterms.subjectlipid peroxidationen
dcterms.subjectsustained deliveryen
dcterms.subject.materiaCiencias Químicases
dcterms.title.subtitleEffects on osteosarcoma cellsen
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