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Effect of hypothyroidism on the composition and turnover rate of islet phospholipids
Effect of hypothyroidism on the composition and turnover rate of islet phospholipids
Cortizo, Ana María
Garcia, M.E.
Pasquini, J.M.
Gagliardino, J.
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Resumen
It has already been demonstrated that the pancreatic B cells of hypothyroid rats have a reduced capacity to release insulin in response to glucose (l). This impaired B cell function may be partly due to a diminished rate of glucose oxidation and net calcium uptake associated with ultrastructural alteration of the pancreatic islets (2). To identify further other factors responsible for this diminished B cell secretory function, we studied the composition and the turnover rate of phospholipids in islets obtained from hypothyroid rats.
Palabras clave
pancreatic B cells
hypothyroid rats
B cell secretory function