Microservices architecture has emerged as a dominant approach for developing scalable and modular software systems, driven by the need for agility and independent deployability. However, designing these architectures poses significant challenges, particularly in service decomposition, inter-service communication, and maintaining data consistency. To address these issues, artificial intelligence (AI) techniques, such as machine learning (ML) and natural language processing (NLP), have been applied with increasing frequency to automate and enhance the design process. This systematic literature review examines the application of AI in microservices design, focusing on AI-driven tools and methods for improving service decomposition, decision-making, and architectural validation. This review analyzes research studies published between 2018 and 2024 that specifically focus on the application of AI techniques in microservices design, identifying key AI methods used, challenges encountered in integrating AI into microservices, and the emerging trends in this research area. The findings reveal that AI has effectively been used to optimize performance, automate design tasks, and mitigate some of the complexities inherent in microservices architectures. However, gaps remain in areas such as distributed transactions and security. The study concludes that while AI offers promising solutions, further empirical research is needed to refine AI’s role in microservices design and address the remaining challenges.