Artículos y presentaciones en Congresos



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  • Resumen
    Acceso Abierto
    Versatility in the biological behavior of two aminobenzoate oxidovanadium (V, IV) compounds. Inhibition or simulation of enzymes
    (2018) Parente, Juliana Elena; Naso, Luciana G.; Jori, Khalil; Arndt, Anderson; Franca, Carlos A.; Costa Ferreira, Ana M. da; Bortolin Uliana, Silvia R.; Pannia Espósito, Breno; Williams, Patricia Ana María; Ferrer, Evelina G.
    The pharmacological potential of vanadium compounds is of great interest to researchers in treatments of various diseases (diabetes, cancer, tropical endemic diseases, etc.). On the basis of the potential biological/pharmacological applications, in this work we have synthesized and physico-chemically characterized, two new complexes containing vanadium (IV) and (V) with 4-aminobenzoic acid as the ligand (L).
  • Artículo
    Acceso Abierto
    Uncertainty studies of topographical measurements on steel surface corrosion by 3D scanning electron microscopy
    (2012) Kang, Kyun Won; Pereda, María Dolores; Canafoglia, María Elena; Bilmes, Pablo David; Llorente, Carlos Luis; Bonetto, Rita
    Pitting corrosion is a damage mechanism quite serious and dangerous in both carbon steel boiler tubes for power plants which are vital to most industries and stainless steels for orthopedic human implants whose demand, due to the increase of life expectation and rate of traffic accidents, has sharply increased. Reliable methods to characterize this kind of damage are becoming increasingly necessary, when trying to evaluate the advance of damage and to establish the best procedures for component inspection in order to determine remaining lives and failure mitigation. A study about the uncertainties on the topographies of corrosion pits from 3D SEM images, obtained at low magnifications (where errors are greater) and different stage tilt angles was carried out by using an in-house software previously developed. Additionally, measurements of pit depths on biomaterial surfaces, subjected to two different surface treatments on stainless steels, were carried out. The different depth distributions observed were in agreement with electrochemical measurements.
  • Artículo
    Potential bio-protective effect of copper compounds: mimicking SOD and peroxidases enzymes and inhibiting acid phosphatase as a target for anti-osteoporotic chemotherapeutics
    (2018) Martini, Nancy; Parente, Juliana Elena; D'Alessandro, Franco; Rey, Marilin; Rizzi, Alberto; Williams, Patricia Ana María; Ferrer, Evelina G.
    Copper complexes with transformed methimazole ligand have been synthesized and characterized by elemental analysis, conductivity measurements, thermogravimetric analysis, EPR, FTIR and UV–Vis spectroscopies. Results support their stoichiometries and geometrical structures: [Cu(C4H5N2S)2Cl2]·2H2O(1), [Cu(C8H10N4S)SO4H2O](2) and [Cu(C8H10N4S)SO4](3). ((C4H5N2)2S: bis(l-methylimidazol-2-yl)sulfide; (C4H5N2S)2 = Bis[bis(l-methylimidazol-2-yl)disulfide]) Concurrently, the structurally distinct soluble species corresponding to complexes (1) and (2) were subsequently used in an in vitro investigation of their potential biological properties. In view of their possible pharmaceutical activity, the complexes were in vitro evaluated as phosphatase acid inhibitors. Their radical bio-protective effects were also studied measuring the effect against DPPH• and O2•− radicals. Additional catalytic properties as peroxidase mimics were evaluated using Michaelis–Menten kinetic model by means of phenol red and pyrogallol assays. The complexes exhibited catalytic bromination activity and the ability to oxidize pyrogallol substrate indicating that they can be considered as functional models. The relationships between the structures and the in vitro biological activities have also been considered. Serum protein albumin has attracted the greatest interest as drug carrier and the affinity of biological/pharmaceutical compound is relevant to the development of new medicine. In that sense, interaction studies by fluorescence and EPR spectroscopies were performed showing the binding capacity of the complexes.
  • Documento de conferencia
    Acceso Abierto
    Sistemas modelos biomiméticos de haloperoxidasas e inhibidores de fosfatasa ácida y alcalina
    (2017) Parente, Juliana Elena; Jori, Khalil; Naso, Luciana G.; Williams, Patricia Ana María; Ferrer, Evelina G.
    El objetivo de esta investigación se centra en el estudio de las potencialidades de los complejos de coordinación con vanadio como simuladores de la actividad desarrollada por las enzimas peroxidasas e inhibidores de la actividad de las fosfatasas.
  • Artículo
    Evidence of promising biological-pharmacological activities of the sertraline-based copper complex: (SerH2)2[CuCl4]
    (Elsevier, 2017) Martini, Nancy; Parente, Juliana Elena; Toledo, María Eugenia; Escudero, Graciela E.; Laino, Carlos; Martínez Medina, Juan José; Echeverría, Gustavo A.; Piro, Oscar E.; Lezama, Luis; Williams, Patricia Ana María; Ferrer, Evelina G.
    In the current study the ability of copper complex to exert multiple biological activities is combined with the pharmacological action of sertraline (SerH2Cl, antidepressant drug). The hydrated and anhydrous forms of the tetrachlorocuprate(II) salts, namely (SerH2)2[CuCl4]·½H2O and (SerH2)2[CuCl4], were synthesized and characterized by physicochemical methods. The crystal structures were determined by X-ray diffraction methods. The hydrate complex crystallizes in the monoclinic P21 space group with a =8.0807(2) Å, b =36.2781(8) Å, c =12.6576(3) Å, β =95.665(2)°, and Z =4 molecules per unit cell and the un-hydrate in P21 with a =13.8727(6) Å, b =7.5090(3) Å, c= 18.618(1) Å, β =104.563(6)°, and Z =2. It has been suggested that Cu(II) ions might be critical in the development of mood disorders, showed potent biocidal activity, and also acted as analgesic adjuvant. To improve sertraline efficiency, the antidepressant and analgesic activities of the complex have been assessed in rats denoting a marked synergistic effect. Antithyroid and antimicrobial activities were also evaluated. Because depressive disorders and hyperthyroidism diseases led to an oxidative stress state, antioxidant capability has also been tested. The complex behaved as a good superoxide radical scavenger (IC50=6.3 × 10−6 M). The ability of the complex to act as bromoperoxidase mimic was assessed. A pseudofirst order constant of k = 0.157 ± 0.007 min−1 has been determined. The complex evidences promising biological-pharmacological activities and the albumin binding studies showed a Kb of 2.90 ×103 M−1 showing an improvement in the uptake of sertraline by albumin at 8 h incubation (time required for effective interaction of sertraline with the protein).