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dc.title Tautomerizable β-ketonitrile copolymers for bone tissue engineering: studies of biocompatibility and cytotoxicity en
dc.type Artículo es
dcterms.abstract β-Ketonitrile tautomeric copolymers have demonstrated tunable hydrophilicity/hydrophobicity properties according to surrounding environment, and mechanical properties similar to those of human bone tissue. Both characteristic properties make them promising candidates as biomaterials for bone tissue engineering. Based on this knowledge we have designed two scaffolds based on β-ketonitrile tautomeric copolymers which differ in chemical composition and surface morphology. Two of them were nanostructured, using an anodized aluminum oxide (AAO) template, and the other two obtained by solvent casting methodology. They were used to evaluate the effect of the composition and their structural modifications on the biocompatibility, cytotoxicity and degradation properties. Our results showed that the nanostructured scaffolds exhibited higher degradation rate by macrophages than casted scaffolds (6 and 2.5% of degradation for nanostructured and casted scaffolds, respectively), a degradation rate compatible with bone regeneration times. We also demonstrated that the β-ketonitrile tautomeric based scaffolds supported osteoblastic cell proliferation and differentiation without cytotoxic effects, suggesting that these biomaterials could be useful in the bone tissue engineering field. en
dcterms.extent 256-262 es
dcterms.issued 2015
dcterms.language Inglés es
dcterms.license Attribution-NonCommercial-ShareAlike 4.0 International (BY-NC-SA 4.0) es
dcterms.subject Tautomeric copolymer en
dcterms.subject Bone tissue engineering en
dcterms.subject Biocompatibility en
dcterms.subject Cytotoxicity assays en
cic.version info:eu-repo/semantics/publishedVersion es Lastra, María Laura es Molinuevo, María Silvina es Giussi, Juan M. es Allegretti, Patricia E. es Blaszczyk Lezak, Iwona es Mijangos, Carmen es Cortizo, María Susana es
cic.lugarDesarrollo Laboratorio de Estudio de Compuestos Orgánicos es
cic.lugarDesarrollo Instituto de Investigaciones Fisicoquímicas Teóricas y Aplicadas es
dcterms.subject.materia Ciencias Biológicas es
dcterms.identifier.other doi:10.1016/j.msec.2015.03.008 es
dcterms.identifier.other ISSN:0928-4931 es
dcterms.isPartOf.issue vol. 51 es
dcterms.isPartOf.series Materials Science and Engineering C es
cic.isPeerReviewed true es
cic.isFulltext true es
cic.institucionOrigen Laboratorio de Investigación en Osteopatías y Metabolismo Mineral es


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