Tautomerizable β-ketonitrile copolymers for bone tissue engineering: studies of biocompatibility and cytotoxicity
| cic.institucionOrigen | Laboratorio de Investigación en Osteopatías y Metabolismo Mineral | es |
| cic.isFulltext | true | es |
| cic.isPeerReviewed | true | es |
| cic.lugarDesarrollo | Laboratorio de Estudio de Compuestos Orgánicos | es |
| cic.lugarDesarrollo | Instituto de Investigaciones Fisicoquímicas Teóricas y Aplicadas | es |
| cic.version | info:eu-repo/semantics/publishedVersion | es |
| dc.date.accessioned | 2021-10-07T18:20:11Z | |
| dc.date.available | 2021-10-07T18:20:11Z | |
| dc.identifier.uri | https://digital.cic.gba.gob.ar/handle/11746/11324 | |
| dc.title | Tautomerizable β-ketonitrile copolymers for bone tissue engineering: studies of biocompatibility and cytotoxicity | en |
| dc.type | Artículo | es |
| dcterms.abstract | β-Ketonitrile tautomeric copolymers have demonstrated tunable hydrophilicity/hydrophobicity properties according to surrounding environment, and mechanical properties similar to those of human bone tissue. Both characteristic properties make them promising candidates as biomaterials for bone tissue engineering. Based on this knowledge we have designed two scaffolds based on β-ketonitrile tautomeric copolymers which differ in chemical composition and surface morphology. Two of them were nanostructured, using an anodized aluminum oxide (AAO) template, and the other two obtained by solvent casting methodology. They were used to evaluate the effect of the composition and their structural modifications on the biocompatibility, cytotoxicity and degradation properties. Our results showed that the nanostructured scaffolds exhibited higher degradation rate by macrophages than casted scaffolds (6 and 2.5% of degradation for nanostructured and casted scaffolds, respectively), a degradation rate compatible with bone regeneration times. We also demonstrated that the β-ketonitrile tautomeric based scaffolds supported osteoblastic cell proliferation and differentiation without cytotoxic effects, suggesting that these biomaterials could be useful in the bone tissue engineering field. | en |
| dcterms.creator.author | Lastra, María Laura | es |
| dcterms.creator.author | Molinuevo, María Silvina | es |
| dcterms.creator.author | Giussi, Juan M. | es |
| dcterms.creator.author | Allegretti, Patricia E. | es |
| dcterms.creator.author | Blaszczyk Lezak, Iwona | es |
| dcterms.creator.author | Mijangos, Carmen | es |
| dcterms.creator.author | Cortizo, María Susana | es |
| dcterms.extent | 256-262 | es |
| dcterms.identifier.other | doi:10.1016/j.msec.2015.03.008 | es |
| dcterms.identifier.other | ISSN:0928-4931 | es |
| dcterms.isPartOf.issue | vol. 51 | es |
| dcterms.isPartOf.series | Materials Science and Engineering C | es |
| dcterms.issued | 2015 | |
| dcterms.language | Inglés | es |
| dcterms.license | Attribution-NonCommercial-ShareAlike 4.0 International (BY-NC-SA 4.0) | es |
| dcterms.subject | Tautomeric copolymer | en |
| dcterms.subject | Bone tissue engineering | en |
| dcterms.subject | Biocompatibility | en |
| dcterms.subject | Cytotoxicity assays | en |
| dcterms.subject.materia | Ciencias Biológicas | es |
Archivos
Bloque original
1 - 1 de 1
Cargando...
- Nombre:
- 2015_Lastra ML_Materials Science and Engineering.pdf-PDFA.pdf
- Tamaño:
- 1.06 MB
- Formato:
- Adobe Portable Document Format
- Descripción:
- Documento completo