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dc.title Advanced glycation end products and strontium ranelate promote osteogenic differentiation of vascular smooth muscle cells in vitro: preventive role of vitamin D en
dc.type Artículo es
dcterms.abstract Advanced glycation end products (AGE) have been demonstrated to induce the osteogenic transdifferentiation of vascular smooth muscle cells (VSMC). Strontium ranelate (SR) is an anti-osteoporotic agent that has both anti-catabolic and anabolic actions on bone tissue. However, in the last years SR has been associated with an increase of cardiovascular risk. We hypothesize that SR can increase the osteoblastic trans-differentiation of VSMC and the induction of extracellular calcifications, an effect that could be potentiated in the presence of AGE and inhibited by simultaneous administration of vitamin D. The present results of our in vitro experiments demonstrate that AGE and SR alone or in combination, stimulate L-type calcium channels, causing an increase in reactive oxygen species and activation of both ERK and NFkB, with the final effect of promoting the osteogenic shift of VSMC. Importantly, these in vitro effects of AGE and/or SR can be prevented by co-incubation with vitamin D. en
dcterms.extent 94-104 es
dcterms.issued 2017
dcterms.language Inglés es
dcterms.license Attribution-NonCommercial-ShareAlike 4.0 International (BY-NC-SA 4.0) es
dcterms.subject Advanced glycation end products en
dcterms.subject Vascular smooth muscle cells en
dcterms.subject Strontium ranelate en
dcterms.subject Osteoblasts en
dcterms.subject Vitamin D en
cic.version info:eu-repo/semantics/publishedVersion es Molinuevo, María Silvina es Fernández, Juan Manuel es Cortizo, Ana María es McCarthy, Antonio Desmond es Schurman, León es Sedlinsky, Claudia es
cic.lugarDesarrollo Laboratorio de Investigación en Osteopatías y Metabolismo Mineral es
dcterms.subject.materia Ciencias Biológicas es
dcterms.identifier.other doi:10.1016/j.mce.2017.04.022 es
dcterms.identifier.other ISSN:0303-7207 es
dcterms.isPartOf.issue vol. 450 es
dcterms.isPartOf.series Molecular and Cellular Endocrinology es
cic.isPeerReviewed true es
cic.isFulltext true es
cic.institucionOrigen Laboratorio de Investigación en Osteopatías y Metabolismo Mineral es


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