Advanced glycation end products and strontium ranelate promote osteogenic differentiation of vascular smooth muscle cells in vitro: preventive role of vitamin D

cic.institucionOrigenLaboratorio de Investigación en Osteopatías y Metabolismo Minerales
cic.isFulltexttruees
cic.isPeerReviewedtruees
cic.lugarDesarrolloLaboratorio de Investigación en Osteopatías y Metabolismo Minerales
cic.versioninfo:eu-repo/semantics/publishedVersiones
dc.date.accessioned2021-10-07T18:47:47Z
dc.date.available2021-10-07T18:47:47Z
dc.identifier.urihttps://digital.cic.gba.gob.ar/handle/11746/11327
dc.titleAdvanced glycation end products and strontium ranelate promote osteogenic differentiation of vascular smooth muscle cells in vitro: preventive role of vitamin Den
dc.typeArtículoes
dcterms.abstractAdvanced glycation end products (AGE) have been demonstrated to induce the osteogenic transdifferentiation of vascular smooth muscle cells (VSMC). Strontium ranelate (SR) is an anti-osteoporotic agent that has both anti-catabolic and anabolic actions on bone tissue. However, in the last years SR has been associated with an increase of cardiovascular risk. We hypothesize that SR can increase the osteoblastic trans-differentiation of VSMC and the induction of extracellular calcifications, an effect that could be potentiated in the presence of AGE and inhibited by simultaneous administration of vitamin D. The present results of our in vitro experiments demonstrate that AGE and SR alone or in combination, stimulate L-type calcium channels, causing an increase in reactive oxygen species and activation of both ERK and NFkB, with the final effect of promoting the osteogenic shift of VSMC. Importantly, these in vitro effects of AGE and/or SR can be prevented by co-incubation with vitamin D.en
dcterms.creator.authorMolinuevo, María Silvinaes
dcterms.creator.authorFernández, Juan Manueles
dcterms.creator.authorCortizo, Ana Maríaes
dcterms.creator.authorMcCarthy, Antonio Desmondes
dcterms.creator.authorSchurman, Leónes
dcterms.creator.authorSedlinsky, Claudiaes
dcterms.extent94-104es
dcterms.identifier.otherdoi:10.1016/j.mce.2017.04.022es
dcterms.identifier.otherISSN:0303-7207es
dcterms.isPartOf.issuevol. 450es
dcterms.isPartOf.seriesMolecular and Cellular Endocrinologyes
dcterms.issued2017
dcterms.languageIngléses
dcterms.licenseAttribution-NonCommercial-ShareAlike 4.0 International (BY-NC-SA 4.0)es
dcterms.subjectAdvanced glycation end productsen
dcterms.subjectVascular smooth muscle cellsen
dcterms.subjectStrontium ranelateen
dcterms.subjectOsteoblastsen
dcterms.subjectVitamin Den
dcterms.subject.materiaCiencias Biológicases
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