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dc.title Study of Materials for Drugs Delivery: cis-[PtCl₂(NH₃)₂] Hydrolysis on Functionalized SiO₂(100) Surfaces en
dc.type Artículo es
dcterms.abstract The hydrolysis of the cis-platin drug on a SiO2(100) hydrated surface was investigated by computational modeling. The cisplatin molecule presents weak interactions with the neighbouring OH groups of the hydrated surface. The cisplatin hydrolysis is not favourable on the SiO2(100) surface. Consequently, the adsorption properties of SiO2(100) are improved considering the surface’s modification with K, Mg, or NH2 functional species. In general, the system is more stable and the molecule-surface distance is reduced when cisplatin is adsorbed on the promoted surfaces.The hydrolysis is a favourable process on the SiO2(100) functionalized surfaces. The cisplatin hydrolysis is most favoured when the surface is functionalized with the NH2 specie. The electron density exchange plays a main role in the adsorption process. cis-[PtCl2(NH3)2] and cis-[PtCl(NH3)2]+ are adsorbed on the functionalized surface via Cl–N and Cl–Si interactions, while the cis-[Pt(NH3)2]2+ complex is adsorbed through Pt–O, Pt–Si, and Pt–Hinteractions. After adsorption, the strength of the N–Si, Si–O, and N–H superficial bonds of the functionalized SiO2(100) changes favouring the interaction between the molecule and their complexes with the surface. en
dcterms.extent 11 p. es
dcterms.issued 2013
dcterms.language Inglés es
dcterms.license Attribution 4.0 International (BY 4.0) es
dcterms.publisher Hindawi Publishing Corporation es
dcterms.subject hydrolysis en
dcterms.subject cisplatin en
cic.version info:eu-repo/semantics/publishedVersion es Díaz Compañy, Andrés Carlos Daniel es Brizuela, G. es Simonetti, S. es
cic.lugarDesarrollo Universidad Nacional del Sur es
dcterms.subject.materia Ciencias Físicas es
dcterms.identifier.url Recurso online es
dcterms.identifier.other DOI: 10.1155/2013/363209 es
dcterms.isPartOf.issue vol. 2013 es
dcterms.isPartOf.series Journal of Solid State Physics es
cic.isPeerReviewed true es
cic.isFulltext true es


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