Regulation of advanced glycation end product (AGE) receptors and apoptosis by AGEs in osteoblast-like cells
Regulation of advanced glycation end product (AGE) receptors and apoptosis by AGEs in osteoblast-like cells
| cic.isFulltext | true | es |
| cic.isPeerReviewed | true | es |
| cic.lugarDesarrollo | Universidad Nacional de La Plata | es |
| cic.version | info:eu-repo/semantics/submittedVersion | es |
| dc.date.accessioned | 2016-12-12T16:51:46Z | |
| dc.date.available | 2016-12-12T16:51:46Z | |
| dc.identifier.uri | https://digital.cic.gba.gob.ar/handle/11746/4960 | |
| dc.title | Regulation of advanced glycation end product (AGE) receptors and apoptosis by AGEs in osteoblast-like cells | en |
| dc.type | Documento de conferencia | es |
| dcterms.abstract | Advanced glycation end products (AGEs) have been proposed as the pathological mechanisms underlying diabetic chronic complications. They may also play a role in the pathogenesis of diabetic osteopenia, although their mechanisms of action remain unclear. We investigated the protein (immunofluorescence) and gene expression (realtime RT-PCR) of two receptors for AGEs, RAGE and galectin-3, as well as their regulation by AGEs, and the apoptotic effect on osteoblast-like cells (UMR106 and MC3T3E1) in culture. AGEs up-regulated the expression of RAGE and galectin-3 in both cells lines. These effects were accompanied by an increase in the corresponding mRNA in the non-tumoral MC3T3E1 but not in the osteosarcoma UMR106 cells. Finally, we demonstrated that a 24 h exposure to AGEs induced apoptosis in both cell lines. Thus, AGEs-receptors may play important roles in the bone alterations described in aging and diabetic patients. | en |
| dcterms.creator.author | Mercer, Natalia | es |
| dcterms.creator.author | Ahmed, Hafiz | es |
| dcterms.creator.author | Etcheverry, Susana B. | es |
| dcterms.creator.author | Vasta, Gerardo R. | es |
| dcterms.creator.author | Cortizo, Ana María | es |
| dcterms.extent | 8 p. | es |
| dcterms.isPartOf.issue | vol. 306 | es |
| dcterms.isPartOf.series | Molecular and Cellular Biochemistry | es |
| dcterms.issued | 2007 | |
| dcterms.language | Inglés | es |
| dcterms.license | Attribution 4.0 International (BY 4.0) | es |
| dcterms.subject | Advanced glycation end products | en |
| dcterms.subject | RAGE | en |
| dcterms.subject | Galectin-3 | en |
| dcterms.subject | Osteoblasts | en |
| dcterms.subject | Apoptosis | en |
| dcterms.subject | AGE-receptors | en |
| dcterms.subject | Regulation | en |
| dcterms.subject.materia | Ciencias Químicas | es |
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