Metformin Reverts Deleterious Effects of Advanced Glycation End-Products (AGEs) on Osteoblastic Cells
| cic.isFulltext | SI | |
| cic.isPeerReviewed | true | |
| cic.lugarDesarrollo | Universidad Nacional de La Plata | |
| cic.parentType | Artículo | |
| cic.version | Publicada | |
| dc.date.accessioned | 2023-06-22T18:40:25Z | |
| dc.date.available | 2023-06-22T18:40:25Z | |
| dc.identifier.uri | https://digital.cic.gba.gob.ar/handle/11746/11951 | |
| dc.title | Metformin Reverts Deleterious Effects of Advanced Glycation End-Products (AGEs) on Osteoblastic Cells | en |
| dc.type | Artículo | |
| dcterms.abstract | Advanced glycation endproducts (AGEs) are implicated in the complications of diabetes and ageing, affecting several tissues, including bone. Metformin, an insulin-sensitizer drug, reduces the risk of life-threatening macrovascular complications. We have evaluated the hypothesis that metformin can abrogate AGE-induced deleterious effects in osteoblastic cells in culture. In two osteoblast-like cell lines (UMR106 and MC3T3E1), AGE-modifi ed albumin induced cell death, caspase- 3 activity, altered intracellular oxidative stress and inhibited alkaline phosphatase activity. Metformin-treatment of osteoblastic cells prevented these AGE-induced alterations. We also assessed the expression of AGE receptors as a possible mechanism by which metformin could modulate the action of AGEs. AGEs-treatment of osteoblast-like cells enhanced RAGE protein expression, and this up-regulation was prevented in the presence of metformin. Although the precise mechanisms involved in metformin signaling are still elusive, our data implicate the AGE-RAGE interaction in the modulation of growth and differentiation of osteoblastic cells. | en |
| dcterms.creator.author | Schurman, León | |
| dcterms.creator.author | McCarthy, Antonio Desmond | |
| dcterms.creator.author | Sedlinsky, Claudia | |
| dcterms.creator.author | Gangoiti, Maria Virginia | |
| dcterms.creator.author | Arnol, Verónica | |
| dcterms.creator.author | Bruzzone, Liliana | |
| dcterms.creator.author | Cortizo, Ana María | |
| dcterms.extent | 333-340 | |
| dcterms.identifier.other | DOI: 0.1055/s-2007-992786 | |
| dcterms.identifier.other | ISSN: 0947-7349 | |
| dcterms.isPartOf.issue | vol. 116, no. 6 | |
| dcterms.isPartOf.series | Experimental and Clinical Endocrinology and Diabetes | |
| dcterms.issued | 2007 | |
| dcterms.language | Inglés | |
| dcterms.license | Attribution-NonCommercial-ShareAlike 4.0 International (BY-NC-SA 4.0) | |
| dcterms.subject | Metformin | es |
| dcterms.subject | Advanced glycation end product | es |
| dcterms.subject | Osteoblasts | es |
| dcterms.subject | Oxidative stress | es |
| dcterms.subject | RAGO | es |
| dcterms.subject.materia | Bioquímica y Biología Molecular |
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