Evidence of promising biological-pharmacological activities of the sertraline-based copper complex: (SerH2)2[CuCl4]

cic.isFulltexttruees
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cic.lugarDesarrolloCentro de Química Inorgánica es
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dc.date.accessioned2018-05-24T15:05:31Z
dc.date.available2018-05-24T15:05:31Z
dc.identifier.urihttps://digital.cic.gba.gob.ar/handle/11746/8102
dc.titleEvidence of promising biological-pharmacological activities of the sertraline-based copper complex: (SerH2)2[CuCl4]en
dc.typeArtículoes
dcterms.abstractIn the current study the ability of copper complex to exert multiple biological activities is combined with the pharmacological action of sertraline (SerH2Cl, antidepressant drug). The hydrated and anhydrous forms of the tetrachlorocuprate(II) salts, namely (SerH2)2[CuCl4]·½H2O and (SerH2)2[CuCl4], were synthesized and characterized by physicochemical methods. The crystal structures were determined by X-ray diffraction methods. The hydrate complex crystallizes in the monoclinic P21 space group with a =8.0807(2) Å, b =36.2781(8) Å, c =12.6576(3) Å, β =95.665(2)°, and Z =4 molecules per unit cell and the un-hydrate in P21 with a =13.8727(6) Å, b =7.5090(3) Å, c= 18.618(1) Å, β =104.563(6)°, and Z =2. It has been suggested that Cu(II) ions might be critical in the development of mood disorders, showed potent biocidal activity, and also acted as analgesic adjuvant. To improve sertraline efficiency, the antidepressant and analgesic activities of the complex have been assessed in rats denoting a marked synergistic effect. Antithyroid and antimicrobial activities were also evaluated. Because depressive disorders and hyperthyroidism diseases led to an oxidative stress state, antioxidant capability has also been tested. The complex behaved as a good superoxide radical scavenger (IC50=6.3 × 10−6 M). The ability of the complex to act as bromoperoxidase mimic was assessed. A pseudofirst order constant of k = 0.157 ± 0.007 min−1 has been determined. The complex evidences promising biological-pharmacological activities and the albumin binding studies showed a Kb of 2.90 ×103 M−1 showing an improvement in the uptake of sertraline by albumin at 8 h incubation (time required for effective interaction of sertraline with the protein).es
dcterms.creator.authorMartini, Nancyes
dcterms.creator.authorParente, Juliana Elenaes
dcterms.creator.authorToledo, María Eugeniaes
dcterms.creator.authorEscudero, Graciela E.es
dcterms.creator.authorLaino, Carloses
dcterms.creator.authorMartínez Medina, Juan Josées
dcterms.creator.authorEcheverría, Gustavo A.es
dcterms.creator.authorPiro, Oscar E.es
dcterms.creator.authorLezama, Luises
dcterms.creator.authorWilliams, Patricia Ana Maríaes
dcterms.creator.authorFerrer, Evelina G.es
dcterms.extentp. 76-89es
dcterms.identifier.otherdoi:10.1016/j.jinorgbio.2017.05.012es
dcterms.identifier.urlRecurso onlinees
dcterms.isPartOf.issuevol. 174es
dcterms.isPartOf.seriesJournal of Inorganic Biochemistryes
dcterms.issued2017-09
dcterms.languageIngléses
dcterms.licenseAttribution-NonCommercial-NoDerivatives 4.0 International (BY-NC-ND 4.0)es
dcterms.publisherElsevieres
dcterms.subjectDrug designen
dcterms.subjectX-ray crystal structureen
dcterms.subjectPharmacological activitiesen
dcterms.subjectBioavailabilityen
dcterms.subject.materiaCiencias Químicases
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