Strontium ranelate stimulates the activity of bone-specific alkaline phosphatase: interaction with Zn2+ and Mg2+
| cic.isFulltext | true | es |
| cic.isPeerReviewed | true | es |
| cic.lugarDesarrollo | Universidad Nacional de La Plata | es |
| cic.version | info:eu-repo/semantics/submittedVersion | es |
| dc.date.accessioned | 2016-11-17T12:58:38Z | |
| dc.date.available | 2016-11-17T12:58:38Z | |
| dc.identifier.uri | https://digital.cic.gba.gob.ar/handle/11746/4725 | |
| dc.title | Strontium ranelate stimulates the activity of bone-specific alkaline phosphatase: interaction with Zn2+ and Mg2+ | en |
| dc.type | Artículo | es |
| dcterms.abstract | Strontium ranelate (SR) is an orally administered and bone-targeting anti-osteoporotic agent that increases osteoblast-mediated bone formation while decreasing osteoclastic bone resorption, and thus reduces the risk of vertebral and femoral bone fractures in postmenopausal women with osteoporosis. Osteoblastic alkaline phosphatase (ALP) is a key enzyme involved in the process of bone formation and osteoid mineralization. In this study we investigated the direct effect of strontium (SR and SrCl$latex ^{_{2}} $further decreased Km in all cases. These direct effects of SR on osteoblastic ALP activity could be indicating an alternative mechanism by which this compound may regulate bone matrix mineralization. | en |
| dcterms.creator.author | Fernández, Juan Manuel | es |
| dcterms.creator.author | Molinuevo, Maria Silvina | es |
| dcterms.creator.author | McCarthy, Antonio Desmond | es |
| dcterms.creator.author | Cortizo, Ana María | es |
| dcterms.extent | 7 p. | es |
| dcterms.isPartOf.issue | vol. 27 | es |
| dcterms.isPartOf.series | BioMetals | es |
| dcterms.issued | 2014 | |
| dcterms.language | Inglés | es |
| dcterms.license | Attribution 4.0 International (BY 4.0) | es |
| dcterms.subject | Bone-specific alkaline phosphatase | en |
| dcterms.subject | Magnesium | en |
| dcterms.subject | Zinc | en |
| dcterms.subject | Strontium ranelate | en |
| dcterms.subject | Osteoblasts | en |
| dcterms.subject.materia | Ciencias Químicas | es |
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