Strontium ranelate stimulates the activity of bone-specific alkaline phosphatase: interaction with Zn2+ and Mg2+

cic.isFulltexttruees
cic.isPeerReviewedtruees
cic.lugarDesarrolloUniversidad Nacional de La Plata es
cic.versioninfo:eu-repo/semantics/submittedVersiones
dc.date.accessioned2016-11-17T12:58:38Z
dc.date.available2016-11-17T12:58:38Z
dc.identifier.urihttps://digital.cic.gba.gob.ar/handle/11746/4725
dc.titleStrontium ranelate stimulates the activity of bone-specific alkaline phosphatase: interaction with Zn2+ and Mg2+en
dc.typeArtículoes
dcterms.abstractStrontium ranelate (SR) is an orally administered and bone-targeting anti-osteoporotic agent that increases osteoblast-mediated bone formation while decreasing osteoclastic bone resorption, and thus reduces the risk of vertebral and femoral bone fractures in postmenopausal women with osteoporosis. Osteoblastic alkaline phosphatase (ALP) is a key enzyme involved in the process of bone formation and osteoid mineralization. In this study we investigated the direct effect of strontium (SR and SrCl$latex ^{_{2}} $further decreased Km in all cases. These direct effects of SR on osteoblastic ALP activity could be indicating an alternative mechanism by which this compound may regulate bone matrix mineralization.en
dcterms.creator.authorFernández, Juan Manueles
dcterms.creator.authorMolinuevo, Maria Silvinaes
dcterms.creator.authorMcCarthy, Antonio Desmondes
dcterms.creator.authorCortizo, Ana Maríaes
dcterms.extent7 p.es
dcterms.isPartOf.issuevol. 27es
dcterms.isPartOf.seriesBioMetalses
dcterms.issued2014
dcterms.languageIngléses
dcterms.licenseAttribution 4.0 International (BY 4.0)es
dcterms.subjectBone-specific alkaline phosphataseen
dcterms.subjectMagnesiumen
dcterms.subjectZincen
dcterms.subjectStrontium ranelateen
dcterms.subjectOsteoblastsen
dcterms.subject.materiaCiencias Químicases
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