Stimulated release of arachidonate and prostaglandins is vectorial in MDCK epithelial cells

cic.isFulltexttruees
cic.isPeerReviewedtruees
cic.lugarDesarrolloUniversidad Nacional de La Plata es
cic.versioninfo:eu-repo/semantics/submittedVersiones
dc.date.accessioned2016-10-25T14:40:33Z
dc.date.available2016-10-25T14:40:33Z
dc.identifier.urihttps://digital.cic.gba.gob.ar/handle/11746/4499
dc.titleStimulated release of arachidonate and prostaglandins is vectorial in MDCK epithelial cellsen
dc.typeArtículoes
dcterms.abstractThe receptor mediated activation of phospholipase A2by appropriate ligands results in the synthesis and release of eicosanoids, a class of potent bioregulatory molecules. Madin-Darby canine kidney cells (MDCK) are polarized epithelial cells, with structurally and functionally distinct plasma membrane domains separated by tight junctions. Using MDCK cells grown in dual sided chambers, we show in this report, that a) the receptor mediated release of prostaglandins and arachidonate into the extracellular medium is predominantly unidirectional, b) the direction of release is agonist specific, and c) the magnitude of the response due to a given agonist is cell-domain specific. These characteristics, if operative<em>in vivo</em>, would contribute towards the optimal function of trans-cellular metabolism of eicosanoids already demonstrated.en
dcterms.creator.authorCortizo, Ana Maríaes
dcterms.creator.authorBesterman, J.M.es
dcterms.creator.authorLeitner, P.P.es
dcterms.creator.authorChandrabose, K.A.es
dcterms.extent15 p.es
dcterms.isPartOf.issuevol. 44, no. 4es
dcterms.isPartOf.seriesProstaglandinses
dcterms.issued1992
dcterms.languageIngléses
dcterms.licenseAttribution 4.0 International (BY 4.0)es
dcterms.subjectphospholipase A2en
dcterms.subjecteicosanoidsen
dcterms.subjectMadin-Darby canine kidney cellsen
dcterms.subject.materiaCiencias Químicases
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