Effects of advanced glycation end-products on the proliferation and differentiation of osteoblast-like cells
| cic.isFulltext | true | es |
| cic.isPeerReviewed | true | es |
| cic.lugarDesarrollo | Universidad Nacional de La Plata | es |
| cic.version | info:eu-repo/semantics/submittedVersion | es |
| dc.date.accessioned | 2016-12-02T18:50:34Z | |
| dc.date.available | 2016-12-02T18:50:34Z | |
| dc.identifier.uri | https://digital.cic.gba.gob.ar/handle/11746/4899 | |
| dc.title | Effects of advanced glycation end-products on the proliferation and differentiation of osteoblast-like cells | en |
| dc.type | Artículo | es |
| dcterms.abstract | Two different lines of osteoblast-like cells were used to investigate the effect of advanced glycation end-products of bovine serum albumin on cell proliferation and differentiation. These parameters were found to be both dose- and time-dependent. Cell proliferation remained unchanged after a 24 h incubation period, it increased after intermediate periods of incubation with advanced glycation end-products, but was found to be depressed after several days incubation. Cellular alkaline phosphatase activity followed a similar pattern: an initial increase induced by advanced glycation end-products was generally followed, after relatively long incubation periods, by a slight but significant decrease in this parameter. 45Ca2+ uptake was only significantly inhibited by advanced glycation end-products after 24 h incubation. These results suggest that advanced glycation end-products directly regulate osteoblast proliferation and differentiation in a dose and time dependent manner. | en |
| dcterms.creator.author | McCarthy, Antonio Desmond | es |
| dcterms.creator.author | Etcheverry, Susana B. | es |
| dcterms.creator.author | Bruzzone, Liliana | es |
| dcterms.creator.author | Cortizo, Ana María | es |
| dcterms.extent | 9 p. | es |
| dcterms.isPartOf.issue | vol. 170, no. 1 | es |
| dcterms.isPartOf.series | Molecular and Cellular Biochemistry | es |
| dcterms.issued | 1997 | |
| dcterms.language | Español | es |
| dcterms.license | Attribution 4.0 International (BY 4.0) | es |
| dcterms.subject | advanced glycation endproducts | en |
| dcterms.subject | diabetes mellitus | en |
| dcterms.subject | osteoblastic cells | en |
| dcterms.subject | cell proliferation | en |
| dcterms.subject | cell differentiation | en |
| dcterms.subject | bone | en |
| dcterms.subject.materia | Ciencias Químicas | es |
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