The genus Potamolithus is the only native representative of the family Tateidae in South America. Six species of Potamolithus have been recorded from Buenos Aires province, on the Argentinean coasts of the Río de la Plata. These coasts are used for different purposes which could affect species of Potamolithus; however, the actual impact of these threats is unknown. The objective of this project is to know the conservation status of the genus Potamolithus in the Pampean region along the coast of the Río de la Plata. For this, seasonal sampling is being carried out at sites with historical records, providing the first population studies (growth and recruitment) of species in this genus and completing anatomical and molecular descriptions. The Argentinean coast of the Río de la Plata has been greatly altered by people and the invasion of Limnoperna fortunei in recent years, which has made it difficult to find specimens of Potamolithus. On IMG, specimens have been observed at various sites, and growth experiments are being carried out both in situ and in the laboratory. Because of the conchological, anatomical, and genetic analyses, five taxonomic entities are distinguished.