Vanadium derivatives act as growth factor--mimetic compounds upon differentiation and proliferation of osteoblast-like UMR106 cells

cic.isFulltexttruees
cic.isPeerReviewedtruees
cic.lugarDesarrolloCentro de Geología Aplicada, Agua y Medio Ambiente es
cic.versioninfo:eu-repo/semantics/submittedVersiones
dc.date.accessioned2016-10-25T13:46:12Z
dc.date.available2016-10-25T13:46:12Z
dc.identifier.urihttps://digital.cic.gba.gob.ar/handle/11746/4497
dc.titleVanadium derivatives act as growth factor--mimetic compounds upon differentiation and proliferation of osteoblast-like UMR106 cellsen
dc.typeArtículoes
dcterms.abstractThe effect of different vanadium compounds on proliferation and differentiation was examined in osteoblast-like UMR106 cells. Vanadate increased the cell growth in a biphasic manner, the higher doses inhibiting cell progression. Vanadyl stimulated cell proliferation in a dose-responsive manner. Similar to vanadate, pervanadate increased osteoblast-like cell proliferation in a biphasic manner but no inhibition of growth was observed. Vanadyl and pervanadate were stronger stimulators of cell growth than vanadate. Only vanadate was able to regulate the cell differentiation as measured by cell alkaline phosphatase activity. These results suggest that vanadium derivatives behave like growth factors on osteoblast-like cells and are potential pharmacological tools in the control of cell growth.en
dcterms.creator.authorCortizo, Ana Maríaes
dcterms.creator.authorEtcheverry, Susana B.es
dcterms.extent6 p.es
dcterms.isPartOf.issuevol. 145, no. 7es
dcterms.isPartOf.seriesMolecular and cellular biochemistryes
dcterms.issued1995
dcterms.languageIngléses
dcterms.licenseAttribution 4.0 International (BY 4.0)es
dcterms.subjectvanadium compoundsen
dcterms.subjectosteoblast-like cellsen
dcterms.subjectproliferationen
dcterms.subjectdifferentiationen
dcterms.subjectbone developmenten
dcterms.subjectgrowth factorsen
dcterms.subject.materiaGeologíaes
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