Osteogenic actions of the anti-diabetic drug metformin on osteoblasts in culture
| cic.isFulltext | true | es |
| cic.isPeerReviewed | true | es |
| cic.lugarDesarrollo | Universidad Nacional de La Plata | es |
| cic.version | info:eu-repo/semantics/submittedVersion | es |
| dc.date.accessioned | 2016-10-13T13:11:23Z | |
| dc.date.available | 2016-10-13T13:11:23Z | |
| dc.identifier.uri | https://digital.cic.gba.gob.ar/handle/11746/4418 | |
| dc.title | Osteogenic actions of the anti-diabetic drug metformin on osteoblasts in culture | en |
| dc.type | Artículo | es |
| dcterms.abstract | An association has been previously established between uncompensated diabetes mellitus and the loss of bone mineral density and/or quality. In this study, we evaluated the effects of metformin on the growth and differentiation of osteoblasts in culture. Treatment of two osteoblast-like cells (UMR106 and MC3T3E1) with metformin (25–500μM) for 24h led to a dose-dependent increase of cell proliferation. Metformin also promoted osteoblastic differentiation: it increased type-I collagen production in both cell lines and stimulated alkaline phosphatase activity in MC3T3E1 osteoblasts. In addition, metformin markedly increased the formation of nodules of mineralization in 3-week MC3T3E1 cultures. Metformin induced activation and redistribution of phosphorylated extracellular signal-regulated kinase (P-ERK) in a transient manner, and dosedependently stimulated the expression of endothelial and inducible nitric oxide synthases (e/iNOS). These results show for the first time a direct osteogenic effect of metformin on osteoblasts in culture, which could be mediated by activation/redistribution of ERK-1/2 and induction of e/ iNOS. | en |
| dcterms.creator.author | Cortizo, Ana María | es |
| dcterms.creator.author | Sedlinsky, Claudia | es |
| dcterms.creator.author | McCarthy, Antonio Desmond | es |
| dcterms.creator.author | Blanco, Alcira | es |
| dcterms.creator.author | Schurman, León | es |
| dcterms.extent | 9 p. | es |
| dcterms.isPartOf.issue | vol. 536 | es |
| dcterms.isPartOf.series | European Journal of Pharmacology | es |
| dcterms.issued | 2006 | |
| dcterms.language | Inglés | es |
| dcterms.license | Attribution 4.0 International (BY 4.0) | es |
| dcterms.subject | Metformin | en |
| dcterms.subject | Osteoblast | en |
| dcterms.subject | Osteoporosis | es |
| dcterms.subject | Diabetes Mellitus | es |
| dcterms.subject.materia | Ciencias Químicas | es |
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